4.9 • 1.1K Ratings
🗓️ 1 November 2025
⏱️ 25 minutes
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Dr. Irwin Goldstein is one of America’s leading sexual health physicians, a pioneer in the field, and the director of San Diego Sexual Medicine.
In this episode, he breaks down his latest research into what’s known as post-SSRI sexual dysfunction (PSSD)—a condition that’s not uncommon but rarely discussed publicly.
He’s found that a class of antidepressants known as SSRIs can cause lasting physiological damage even after patients discontinue the medication—contrary to what many patients are told.
“When they stop the medicine, the usual teaching is that everyone returns to their pre-medication sexual function, and that’s not what we’re seeing in our sexual health clinic here,” Dr. Goldstein says.
His recent research showed that SSRIs can cause structural damage to genital tissue as well as many other physiological problems, like genital numbness, erectile dysfunction, and loss of libido. These problems persist long-term after discontinuing SSRI antidepressants.
“It’s kind of an awful thing, and it doesn’t go away,” Dr. Goldstein says. “These individuals in my clinic who have been given the medicines: Our youngest is age 11. They'll never experience what one would otherwise consider a normal sexual life.”
Dr. Goldstein holds a degree in engineering from Brown University and a medical degree from McGill University in Montreal. He is credited with advancing the study and treatment of both male and female sexual dysfunctions and has authored more than 360 academic publications in the field.
Views expressed in this video are opinions of the host and the guest, and do not necessarily reflect the views of The Epoch Times.
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| 0:00.0 | It's an awful condition causes frustration, embarrassment, humiliation, and it doesn't go away. |
| 0:08.0 | Dr. Erwin Goldstein is one of America's leading sexual health physicians. |
| 0:12.0 | Many young people who are prescribed SSRI antidepressants are coming to him for help, for lasting damage they've suffered. |
| 0:19.0 | In this episode, he breaks down his latest research into what's known as post-SSRI sexual dysfunction, |
| 0:26.4 | PSSD, a condition that's not uncommon, but rarely discussed publicly. |
| 0:31.2 | These individuals in my clinic who have been given the medicines our youngest as age 11, |
| 0:37.3 | they'll never experience what one would otherwise consider a normal sexual life. |
| 0:43.3 | This is American Thought Leaders, and I'm Yanya Kellick. |
| 0:51.3 | Dr. Erwin Goldstein, such a pleasure to have you on American Thought Leaders. |
| 0:56.4 | Thank you so much for having me. It's a great honor. |
| 1:00.2 | So you've just presented some incredibly important data at a conference. |
| 1:05.4 | You have found that in post-SSRI sexual dysfunction, that there's actual physiological damage that's happening to people, |
| 1:13.8 | including young people that are on these drugs? |
| 1:17.2 | That is a true statement. |
| 1:20.2 | So explain to me the whole picture here. What's going on? |
| 1:25.9 | Wow. |
| 1:34.7 | SSRIs, selective serotonin re-uptake inhibitors are one of the most widely prescribed medications in the United States. They decrease the suicide rate of people |
| 1:44.0 | with major depressive disorder and other mood issues |
| 1:48.5 | and have been found to be really life-changing by psychiatrists and individuals with mood disorders. |
| 1:59.3 | The problem is they are recognized to raise serotonin, |
| 2:04.6 | that's their mechanism, |
| 2:06.6 | but serotonin is an inhibitor of sexual function. |
... |
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