New Alzheimer’s Drug, Bangladeshi Water Machine, Recording Earth’s Sounds. Sept 30, 2022, Part 1
Science Friday
Science Friday and WNYC Studios
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🗓️ 30 September 2022
⏱️ 47 minutes
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Summary
This week, the biotech firms Biogen and Eisai released preliminary data from the clinical trials for their new Alzheimer’s drug, lecanemab. The companies said that the drug slowed cognitive decline by 27% in patients treated with the intravenous medication. It’s likely the drug will get the FDA’s approval by the end of the year.
This all comes after the recent controversy surrounding Biogen’s last Alzheimer’s drug Aduhelm. Medicare recently announced that they will not cover that drug and others like it, unless patients are enrolled in a clinical trial.
Guest host John Dankosky talks with science journalist Roxanne Khamsi about this and other top science news of the week including a diamond that hints that Earth’s mantle contains water, brainy birds, and hearing aids made of false teeth.
Bangladeshi Farmers Found A Way To Save Massive Amounts Of Water
The People’s Republic of Bangladesh is one of the most densely populated countries on Earth, with a population of 165 million people living in an area a bit smaller than the state of Iowa. To feed all those people, farmers in Bangladesh work year-round: Instead of just growing crops during the rainy monsoon season, they grow a second or even third crop during the dry season—using groundwater to irrigate, and creating a more food-secure region.
Research published in the journal Science this month found something amazing about all that groundwater. By pumping water for crops in the dry season, Bangladeshi farmers were leaving space in the aquifers to recharge during the rainy monsoon season. And this space allowed the aquifers to recapture more than 20 trillion gallons of water, or twice the capacity of China’s massive Three Gorges Dam, over the last 30 years.
The researchers call this the Bengal Water Machine, evidence for a similar concept that was first proposed nearly 50 years ago called the Ganges Water Machine.
Guest host John Dankosky talks to lead author Mohammad Shamsudduha and International Water Management Institute researcher Aditi Mukherji about how this groundwater pumping benefits farmers, and the need for more data as climate change continues.
This Soundscape Artist Has Been Listening To The Planet For Decades
Jim Metzner is one of the pioneers of science radio—he’s been making field recordings and sharing them with audiences for more than 40 years. He hosted shows such as “Sounds of Science” in the 1980s, which later grew into “Pulse of the Planet,” a radio show about “the sound of life on Earth.”
Over the decades, Metzner has created an incredible time capsule of soundscapes, and now, his entire collection is going to the Library of Congress.
John Dankosky talks with Metzner about what he’s learned about the natural world from endless hours of recordings and what we can all learn from listening. Plus, they’ll discuss some of his favorite recordings. To hear the best audio quality, it might be a good idea to use headphones if you can.
Transcript
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| 0:00.0 | This is Science Friday. I'm John Denkowski in for Iroflado. Later this hour how farmers in |
| 0:06.0 | Bangladesh are capturing monsoon rains for the next dry season. It's an invisible water machine. |
| 0:12.3 | Plus a conversation with a pioneer in science radio, Jim Metzner. We'll talk about the lessons |
| 0:17.0 | he's learned from carefully listening to the pulse of our planet. But first this week, |
| 0:22.5 | the biotech firms Biogen and Esai released preliminary data from the clinical trials for their new |
| 0:28.3 | Alzheimer's drug. They say the drug is effective in reducing cognitive decline by 27% for patients |
| 0:35.0 | in the trial. And it appears likely the medicine will get the FDA's approval by the end of the year. |
| 0:40.9 | All this comes after the recent controversy surrounding biogen's previous Alzheimer's drug |
| 0:45.5 | Aduhelm, which Medicare and other private insurers will not cover. Joining me now to talk more about |
| 0:50.8 | this and other top science stories of the week is my guest, Roxanne Camsey, a science journalist |
| 0:54.9 | based in Montreal, Quebec, Canada. Roxanne, welcome back to Science Friday. |
| 0:59.1 | Hi, John. It's great to be here. So to start off, tell us more about this new |
| 1:02.8 | intravenous Alzheimer's medicine, Lecana Mab. How effective is it? |
| 1:07.0 | Well, as you say, it only seems to slow the effect of cognitive decline by about a quarter. |
| 1:13.2 | And really it's on the scale from zero to 18. Rupel were being tested on this cognitive test |
| 1:19.6 | called the clinical dementia rating. And they found that people over 18 months who were on the drug |
| 1:26.6 | did point four, five points better. So not quite a stunning difference, I would say, |
| 1:34.2 | than those who didn't receive the drug. So I mean, it kind of comes down to how you calculate it. |
| 1:39.6 | I think the interesting thing here is that we've gone almost 20 years without new drugs for Alzheimer's. |
| 1:45.2 | And now in the last two years, this is the second one. As you mentioned, the first one has kind of |
| 1:51.8 | not been a home run for the drug companies and for patients. So it's a little bit of a way to see |
| 1:57.3 | what this one too, I think. Yeah. And I think a lot of the reaction to it is because we haven't |
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