4.8 • 678 Ratings
🗓️ 23 May 2025
⏱️ 14 minutes
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0:00.0 | Hi, this is Tom, and in this episode I'm going to be going through neonatal jaundice, |
0:09.0 | and you can find notes at zero to finals.com slash jaundice and in the zero to finals pediatrics book. |
0:16.5 | So let's jump straight in. |
0:19.7 | Jaundice describes raised Billy Rubin, leading to yellowing of the skin and the sclure, which is the whites of the eyes. |
0:30.4 | Kurnicturus is a type of brain damage caused by excessive Billy Rubin levels. |
0:38.0 | Billy Rubin can cross the blood-brain barrier and cause direct and permanent damage to the |
0:43.1 | central nervous system, potentially leading to cerebral palsy, learning disabilities and deafness. |
0:51.8 | Let's talk about unconjugated and conjugated bilirubin. |
0:57.9 | Red blood cells contain unconjugated bilirubin. |
1:02.9 | When the red blood cells break down, they release unconjugated bilirubin into the blood. |
1:10.7 | Unconjugated bilirubin is conjugated in the liver. Conjugated |
1:16.8 | bilirubin is excreted in two ways, via the billory system into the gastrointestinal tract and |
1:25.1 | via the urine. Let's talk about physiological jaundice. The fetus and neonate have a high |
1:34.5 | concentration of red blood cells, which are more fragile than normal red blood cells. |
1:40.9 | The fetus and neonate also have less developed liver function. |
1:47.3 | Fetal red blood cells break down more rapidly than normal red blood cells, releasing lots of bilirubin. |
1:54.0 | Normally this bilirubin is excreted via the placenta. |
1:58.8 | However, after birth, the newborn can no longer excrete bilirubin via the placenta. However, after birth, the newborn can no longer excrete Billy Rubin |
2:03.1 | via the placenta, leading to a rise in Billy Rubin from days 2 to 7 of age. This rise in |
2:11.7 | Billy Rubin usually resolves within 10 days of being born. In premature babies, an immature liver can exaggerate the physiological jaundice, |
2:22.8 | increasing the risk of complications, particularly conicterous. |
2:27.8 | Billerubin levels need to be monitored closely in premature babies. |
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