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The Zero to Finals Medical Revision Podcast

Neonatal Jaundice (2nd edition)

The Zero to Finals Medical Revision Podcast

Thomas Watchman

Life Sciences, Education, Medical Finals, Medicine, Surgery, Health & Fitness, Paediatrics, Medical Student, Medical Education, Medical Exams, Medical School, Medical Revision, Science, Learn Medicine, Finals Revision, Obstetrics And Gynaecology

4.8678 Ratings

🗓️ 23 May 2025

⏱️ 14 minutes

🧾️ Download transcript

Summary

This episode covers neonatal jaundice. Written notes can be found at https://zerotofinals.com/paediatrics/neonatology/jaundice/ Questions can be found at https://members.zerotofinals.com/ Books can be found at https://zerotofinals.com/books/ The audio in the episode was expertly edited by Harry Watchman.

Transcript

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0:00.0

Hi, this is Tom, and in this episode I'm going to be going through neonatal jaundice,

0:09.0

and you can find notes at zero to finals.com slash jaundice and in the zero to finals pediatrics book.

0:16.5

So let's jump straight in.

0:19.7

Jaundice describes raised Billy Rubin, leading to yellowing of the skin and the sclure, which is the whites of the eyes.

0:30.4

Kurnicturus is a type of brain damage caused by excessive Billy Rubin levels.

0:38.0

Billy Rubin can cross the blood-brain barrier and cause direct and permanent damage to the

0:43.1

central nervous system, potentially leading to cerebral palsy, learning disabilities and deafness.

0:51.8

Let's talk about unconjugated and conjugated bilirubin.

0:57.9

Red blood cells contain unconjugated bilirubin.

1:02.9

When the red blood cells break down, they release unconjugated bilirubin into the blood.

1:10.7

Unconjugated bilirubin is conjugated in the liver. Conjugated

1:16.8

bilirubin is excreted in two ways, via the billory system into the gastrointestinal tract and

1:25.1

via the urine. Let's talk about physiological jaundice. The fetus and neonate have a high

1:34.5

concentration of red blood cells, which are more fragile than normal red blood cells.

1:40.9

The fetus and neonate also have less developed liver function.

1:47.3

Fetal red blood cells break down more rapidly than normal red blood cells, releasing lots of bilirubin.

1:54.0

Normally this bilirubin is excreted via the placenta.

1:58.8

However, after birth, the newborn can no longer excrete bilirubin via the placenta. However, after birth, the newborn can no longer excrete Billy Rubin

2:03.1

via the placenta, leading to a rise in Billy Rubin from days 2 to 7 of age. This rise in

2:11.7

Billy Rubin usually resolves within 10 days of being born. In premature babies, an immature liver can exaggerate the physiological jaundice,

2:22.8

increasing the risk of complications, particularly conicterous.

2:27.8

Billerubin levels need to be monitored closely in premature babies.

...

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