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Science Quickly

Neandertal DNA May Be COVID Risk

Science Quickly

Scientific American

Science

4.31.4K Ratings

🗓️ 11 October 2020

⏱️ 3 minutes

🧾️ Download transcript

Summary

A stretch of Neandertal DNA has been associated with some cases of severe COVID-19, but it’s unclear how much of a risk it poses. Christopher Intagliata reports. 

Transcript

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0:00.0

May I have your attention please you can now book your train tickets on Uber and get

0:08.0

10% back in credits to spend on your next Uber ride so you don't have to walk home in the rain again.

0:15.0

Trains, now on Uber. T's and C's apply. Check the Uber app.

0:20.0

This is scientific American's 60 second science.

0:27.0

I'm Christopher and Tagata.

0:29.0

The risk factors for COVID-19 are many.

0:32.0

Old age, obesity, heart conditions, but early genetic studies have

0:36.1

identified another trait that some people who develop severe COVID-19 seem to share, a cluster of

0:41.9

genetic variations on their third chromosome.

0:44.9

And that DNA sequence likely derives from Neanderthals, says Hugo Seberg of the Max Planck Institute.

0:50.9

It is quite striking that this variant has lingered on for 50,000 years.

0:56.0

50,000 years ago is the approximate time humans and Neanderthal's interbred.

1:00.0

And over the millennia, those Neanderthal variants have become more common in some Homo sapiens populations than others.

1:07.0

For example, about 16% of people of European descent carry at least one copy of the Neanderthal stretch, half of South Asians do, and nearly two-thirds of Bangladeshis.

1:18.0

And that's kind of fascinating that it is so high, I mean that that points towards that it must have been beneficial in the past.

1:25.0

I mean it's much higher than we expect and then it's totally expunged in East Station and China.

1:32.0

So something has happened. East Station and China.

1:33.0

Some things have happened, driving the frequency in certain placing and removing it totally in other places.

1:40.0

The details are in the journal Nature.

1:42.0

Seaberg and his colleague write that perhaps the Neanderthal DNA happens to boost the risk

1:46.7

of developing severe COVID-19, and they point to the fact that in the UK, people of

1:51.4

Bangladeshi descent have twice the risk of dying of

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