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Nature Podcast

Nature Podcast: 29 October 2015

Nature Podcast

podcast@nature.com

Science, Technology, News

4.5893 Ratings

🗓️ 28 October 2015

⏱️ 26 minutes

🧾️ Download transcript

Summary

This week, how cancers spread, the hallmarks of bipolar disorder in the brain, and making carbon dioxide useful.

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Transcript

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0:00.0

This week, finding a use for carbon dioxide.

0:05.0

Right now it's considered a waste. We just release it into the atmosphere and do nothing with it.

0:11.0

And stem cells offer a test bed for therapies aimed at bipolar disorder.

0:16.0

We would be able to take cells from patients that have had an episode, and we could screen these

0:22.1

cells to assist the physician in the prescription of drugs they'd be most effective.

0:28.0

Plus tracking cancers to stop their spread. This is the Nature Podcast for October the 29th,

0:33.3

2015. I'm Kerry Smith. And I'm Adam Levy.

0:40.5

Our cells get rid of waste proteins in little packages called exosomes that float around in our blood before being flushed from the body.

0:49.0

Cancer cells are no exception. They shed exosomes too. That means they can be detected in the blood

0:55.3

and potentially used to diagnose cancers early. This might ring a bell because on the show

1:00.7

back in June we had researcher Raghu Kuluri and he had been working on using exosomes to

1:05.7

catch cancer. And our interest was to ask the question, since every cell type releases these particles called exosomes,

1:14.7

is there a way to identify them that are released by the cancer cells?

1:19.7

And that would then give us an idea of the cancer load that the patient may have

1:25.9

and what type of things that you can identify in the

1:28.6

exosome that could potentially be being derived from the cancer cells.

1:33.2

Raghu Kuluri from the University of Texas back in June. Now, a group of researchers has moved

1:38.7

the story on. They say that not only can they diagnose cancer, they can predict its next move.

1:45.1

You see, exosomes have been shown to play an important role in metastasis,

1:49.5

the process by which a tumor spreads to other organs.

1:52.9

Exosomes act a bit like scouts seeking out new locations

1:56.2

and preparing the sites for tumor cells to grow in.

...

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