Hello and welcome to the zero definals podcast. My name is Tom and in this episode I'm going to be

talking to you about myeloproliferative disorders. And if you want to follow along with written notes on this

topic, you can follow along at zero definals.com slash myeloproliferative disorders or in the

hematology section of the zero definals medicine book.

So let's get straight into it.

These conditions occur due to uncontrolled proliferation of a single type of stem cell.

And they're considered to be a type of bone marrow cancer.

And there's three myeloproliferative disorders that you need to remember for your exam.

The first is primary myelofibrosis.

The second is polycythemia vera.

And the third is essential thrombocytemia.

Primary myelofibrosis is the result of proliferation of the hematopoetic stem cell.

Polycythemia vera is the result of the proliferation of the erythroid cell line.

And essential thrombosythemia is a result of proliferation of the megacaryocytic cell line.

And remember, megacaryocytes are what creates platelets.

So just to recap that, there's a proliferating cell line and they cause a disease.

So the hematopoetic stem cell creates primary myelofibrosis when it proliferates,

erythroid cells when they proliferate, create polycythemia vera, and megacaryocytes when they proliferate,

create essential thrombosythemia. Miloproliferative disorders have the potential to progress and transform into acute myeloid leukemia.

And this is a transformation you need to remember.

So these myeloprelifrative disorders, whichever one it is, can transform into AML.

And these conditions are associated with mutations in certain genes, the

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