Muscle Preservation with GLP-1 Drugs - Dr. Anurag Singh : 1156

The Human Upgrade with Dave Asprey

Dave Asprey

Fat, Health & Fitness, Meditation, Biohacking, Lifestyle, Diet, Science, Self-improvement, Fasting, Nutrition, Hacking, Fitness, Brain, Wellness, Education

4.6 • 7.3K Ratings

🗓️ 2 May 2024

⏱️ 77 minutes

🔗️ Recording | iTunes | RSS

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Summary

Today on The Human Upgrade, Dr. Anurag Singh, a renowned expert in muscle biology and aging, shares his expertise on the impact of GLP-1 agonists like Ozempic and Wegovy on weight loss, muscle health, and aging. In this episode, you'll learn about the science behind these popular drugs, their potential benefits, and the risks involved. Discover how you can maintain muscle mass while losing weight, enhance your mitochondrial function for better health, and what the future holds for medical treatments in weight management. Gain expert insights into making smart choices for your long-term health and wellness, whether you're considering these treatments or just curious about new health technologies.

Timestamped Highlights:

(00:00:00) Introduction to GLP-1 agonists and their popularity in weight loss.
(00:01:40) Guest introduction: Dr. Anurag Singh's expertise and background.
(00:02:50) Dr. Singh discusses the primary functions and uses of GLP-1 drugs.
(00:06:23) The significant muscle loss associated with GLP-1 drug use.
(00:10:01) Addressing common misconceptions and concerns about GLP-1 agonists.
(00:15:34) How GLP-1 agonists affect mitochondrial function and overall metabolism.
(00:20:30) Comparing the effects of fasting to GLP-1 drugs on weight loss and muscle preservation.
(00:28:43) New testing methods for mitochondrial function and their implications.
(00:35:00) Potential future directions in GLP-1 treatment and muscle preservation strategies.
(00:41:48) The concept of 'Ozempic face' and its effects on personal appearance and self-esteem.
(00:50:04) Discussion on 'Urolithin A' and its role in mitochondrial health and muscle strength.
(01:04:02) Predictions for the next innovations in weight loss and muscle health treatments.

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Transcript

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0:00.0	You're listening to the human upgrade with Dave Asprey.
0:04.0	You're listening to the human upgrade with Dave Asprey.
0:10.0	Today we're going to talk about something that is near and dear to my heart. It is losing weight.
0:16.6	If you've been listening for more than five minutes, you probably know that I lost a
0:21.0	hundred pounds and I've kept it off for a long time.
0:24.0	My medical grade equipment from Upgrade Labs continues to repeat that I'm at 6% body fat and I'm never hungry. So it's almost like this biohacking thing works and it keeps
0:36.4	working. But if I go back to when I was heavily overweight, if I could have taken Ozempik or Wigovi or one of the GLP1 drugs, I absolutely
0:49.7	would have because I had tried everything on the planet to lose weight.
0:54.0	So when these drugs first came out, I think before the big trend happened, I had one of the senior researchers come on the show and I tried it for one week.
1:02.0	I feel like I had morning sickness the whole time. come on the show and I tried it for one week.
1:03.0	I feel like I had morning sickness the whole time and said,
1:05.8	good God, I don't really want to feel this way.
1:07.8	But there is good evidence that low-dose GLP1 agonists are good for longevity.
1:15.0	Maybe not at the same doses that we might take for weight loss.
1:20.0	And I know that a lot of people get offended, well these are pharmaceuticals, you shouldn't do it.
1:24.0	Well, they're actually peptides.
1:25.8	They're signaling molecules in your body and there's a case for losing weight being more important than whatever side effects might happen.
1:37.0	Speaking of that, magically, the danger coffee just arrived.
1:42.0	Our guest today, Dr. Anirab Singh, is an expert in things like
1:45.8	Osmbic and Wigavi because he understands aging and he's
1:52.8	going to go deep on these topics.
1:55.2	He's the chief medical officer of timeline nutrition,
	...

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