Move Over, CRISPR — New Gene Editing Tech is Here
Curiosity Weekly
Warner Bros. Discovery
4.6 • 963 Ratings
🗓️ 14 June 2021
⏱️ 12 minutes
🧾️ Download transcript
Summary
Learn about the RLR gene editing tool; Victorian-era emoji; and why “night shift” screen settings don’t help you sleep.
RLR is a new gene editing tool that's safer and more useful than CRISPR by Cameron Duke
- Move over CRISPR, the retrons are coming. (2021). EurekAlert! https://www.eurekalert.org/pub_releases/2021-04/wifb-moc042921.php
- Schubert, M. G., Goodman, D. B., Wannier, T. M., Kaur, D., Farzadfard, F., Lu, T. K., Shipman, S. L., & Church, G. M. (2021). High-throughput functional variant screens via in vivo production of single-stranded DNA. Proceedings of the National Academy of Sciences, 118(18), e2018181118. https://doi.org/10.1073/pnas.2018181118
- Swingle, B., Markel, E., & Cartinhour, S. (2010). Oligonucleotide recombination: A hidden treasure. Bioengineered Bugs, 1(4), 265–268. https://doi.org/10.4161/bbug.1.4.12098
- Irving, M. (2021, May 4). Harvard gene-editing tool “sneaks” DNA into cells without making cuts. New Atlas. https://newatlas.com/biology/retron-library-recombineering-gene-editing-crispr/
- Are Retrons the Next CRISPR? | Cell And Molecular Biology. (2021). Labroots. https://www.labroots.com/trending/cell-and-molecular-biology/20347/retrons-crispr
Flowers Were Emoji For Victorians by Anna Todd
- Romie Stott. (2016, August 15). How Flower-Obsessed Victorians Encoded Messages in Bouquets. Atlas Obscura; Atlas Obscura. https://www.atlasobscura.com/articles/how-flowerobsessed-victorians-encoded-messages-in-bouquets
- The meaning of flowers, Floriography, language of flowers, advice hints and tips from All Florists.co.uk. Allflorists.co.uk. http://www.allflorists.co.uk/advice_flowerMeanings.asp
"Night shift" screen settings don't really help you sleep by Kelsey Donk
- Is night shift really helping you sleep better? (2021). EurekAlert! https://www.eurekalert.org/pub_releases/2021-04/byu-ins042621.php
- Duraccio, K. M., Zaugg, K. K., Blackburn, R. C., & Jensen, C. D. (2021). Does iPhone night shift mitigate negative effects of smartphone use on sleep outcomes in emerging adults? Sleep Health. https://doi.org/10.1016/j.sleh.2021.03.005
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Transcript
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| 0:00.0 | Hi, you're about to get smarter in just a few minutes with Curiosity Daily from Curiosity.com. |
| 0:06.0 | I'm Cody Gough. And I'm Ashley Hamer. |
| 0:08.0 | Today you learn about a new gene editing tool that could be safer and more useful than CRISPR, |
| 0:13.0 | the Victorian-era equivalent of emoji, |
| 0:16.0 | and why night shift screen settings don't really help you sleep. |
| 0:20.0 | Let's satisfy some curiosity. |
| 0:22.0 | So Ashley, we're starting the week pretty late, right? |
| 0:25.0 | You've got a fluffy little story about what was it again? |
| 0:28.0 | The future of the human race? |
| 0:31.0 | I mean, let's not go overboard here. But on the scale of things this is actually a pretty big deal? |
| 0:38.6 | Yeah pretty big deal. Pretty big deal. Cool. Yeah so you've heard us talk about CRISPR-KAS-9. |
| 0:44.6 | That's a method of gene editing that revolutionized the concept of genetic engineering. |
| 0:49.9 | It's sometimes described as a genetic cut-and-paste tool that can cut out any gene you want, which |
| 0:54.5 | enables scientists to create brand new genomes. |
| 0:58.5 | As big of a deal as it is, though, it turns out that CRISPR has its problems. |
| 1:03.0 | Luckily, new research suggests that there might be a better way. |
| 1:07.0 | As a refresher, CRISPR-CAS-9 is a programmable protein. |
| 1:11.0 | It's like a dog that can be shown a series of letters |
| 1:14.6 | that comprise a particular genetic sequence and then sniff that sequence out of |
| 1:19.1 | an incredibly large genome. When it finds it, it bites, which breaks the DNA. That's how scientists |
| 1:26.3 | have been able to do everything from eliminating HIV from infected cells to creating new |
| 1:31.7 | non-GMO crops. |
... |
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