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ZOE Science & Nutrition

Most replayed moment: Fix Your Gut: Improve Your Mind | Dr Will Bulsiewicz

ZOE Science & Nutrition

ZOE

Nutrition, Education, Science, Health & Fitness

4.65.6K Ratings

🗓️ 28 April 2026

⏱️ 15 minutes

🧾️ Download transcript

Summary

Today, we’re exploring the brain-gut axis We’ve all heard phrases like “gut instinct” or “trust your gut”. These sayings hint towards a sort of mind in your midriff - and it turns out there is some truth to it. Emerging science reveals that the brain and gut are, in fact, closely connected, constantly exchanging signals through this intricate network of nerves. So, the question is: if they’re so tightly intertwined, can treating one help heal the other? I’m joined by gastroenterologist Dr. Will Bulsiewicz to unravel the mystery of this connection - and find out how we can use it to our advantage. 🌱 Try our science-backed and tasty wholefood supplement Daily 30+ Get our brand-new app and Gut Health Test designed by world-leading gut health and nutrition scientists to build healthy eating habits 👉 Join ZOE Follow ZOE on Instagram. 📚Books by our ZOE Scientists The Food For Life Cookbook Every Body Should Know This by Dr Federica Amati Food For Life by Prof. Tim Spector Ferment by Prof. Tim Spector Free resources from ZOE Eating for Better Brain Health: Your brain-gut blueprint How to eat in 2026 - Discover ZOE’s 8 nutrition principles for long-term health Live Healthier: Top 10 Tips From ZOE Science & Nutrition Gut Guide - For a Healthier Microbiome in Weeks  Better Breakfast Guide

Transcript

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0:00.0

Hello and welcome to Zoe Recap, where each week we find the best bits from one of our podcast episodes to help you improve your health.

0:09.0

We've all heard phrases like gut instinct or trust your gut.

0:15.0

And these sayings hint towards a sort of mind in your midriff.

0:19.0

And it turns out there's actually some truth to it.

0:22.3

Emerging science reveals that the brain and the gut are closely connected, constantly exchanging

0:28.1

signals through an intricate network of nerves. So the question is, if they're so tightly

0:33.6

intertwined can treating one help heal the other. I'm joined by gastroenterologist Dr. Will

0:40.6

Bolshewish to unravel the mystery of this connection and find out how we can use it to our

0:45.3

advantage. There is tremendous overlap between digestive health and mood. And we see this

0:53.4

represented in a powerful way in this particular condition

0:56.5

your oral bowel syndrome. Because yes, the criteria are not based upon your mood. The criteria

1:01.6

are based upon your gut, based upon your gut symptoms. But the issue is that a huge percentage

1:07.0

of these people simultaneously are dealing with mood issues. So it's roughly 50% of

1:13.1

people that have your old bowel syndrome that actually can be diagnosed with major depression

1:19.5

or generalized anxiety disorder or both. 50% of people with IBS can be diagnosed with like serious depression or anxiety.

1:30.2

Up to 50% at a minimum 50% are suffering in a way where if you were to measure their mood,

1:35.6

compare that to normal people. At a minimum, they're in a depressed mood relative to other people.

1:39.7

But it is a very large percentage of people that are that are potentially able to be diagnosed with

1:45.7

one of these two conditions or both which are which are mood disorders so there's this overlap

1:51.0

between irritable bowel syndrome and these disorders of our mood and the question that has come up is

1:57.6

like sort of a chicken or egg thing, right? What causes what?

2:01.8

And in the past, like in the very beginning, Jonathan, when they first started studying this,

...

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