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Hospital and Internal Medicine Podcast

Morphine for later stage COPD patients not on hospice

Hospital and Internal Medicine Podcast

Gil Porat, M.D., FACP, CPT

Health & Fitness, Fitness, Science, Health & Fitness:medicine, Medicine

4.7587 Ratings

🗓️ 9 April 2021

⏱️ 9 minutes

🧾️ Download transcript

Summary

Does regular, low-dose, oral sustained-release morphine improve disease-specific health status or cause respiratory adverse effects in patients with moderate to very severe chronic breathlessness due to advanced chronic obstructive pulmonary disease? Digging in on the latest study.

Transcript

Click on a timestamp to play from that location

0:00.0

Welcome back, everybody. I was just reading an article that was stuck in my article pile list,

0:06.6

and this one is actually back from October 17th of 2020, but it struck me that I probably should

0:13.1

talk a little bit about this. As many of you know, I have a soft spot in medicine for when we do

0:20.6

things a certain way, either because

0:22.6

of logic or out of fear, and then we find evidence-based medicine that makes us question whether

0:28.6

we were practicing the correct way. And as you get older, you have more and more of these

0:33.6

experiences in medicine. And I would say that the thing that's making me feel old these days is aging.

0:40.3

And the other thing that makes me feel old is I actually read medical studies, which

0:44.3

I'm learning more and more is not done as much these days.

0:49.3

I have been recently told that CME money in our department is rarely spent on journal subscriptions

0:55.9

because nobody reads journals anymore. So for those of you who don't, you can listen to dinosaurs

1:00.9

like me. So this article was from the August 17th, 2020 Journal of American Medical Association,

1:08.7

and it was titled, Effect of Sustained Release Morphine for Refractory Breathlessness and Chronic Obstructive Pulmonary

1:16.0

Disease on Health Status.

1:18.3

And I just got out of breath saying that entire title without taking a breath.

1:22.6

So maybe I should get my PFTs checked.

1:25.3

In the meantime, let me tell you about this trial. It was a small

1:28.6

trial, but it was a randomized clinical trial. And the patients that were randomized had advanced

1:35.4

chronic obstructive pulmonary disease. Now, many of you who treat this, of course, know

1:40.8

that we're very limited in what we can do with this disease, meaning once we've

1:44.9

maximized all the long-acting and short-acting inhalers, sent people to pulmonary rehab,

1:52.0

utilize oxygen therapy, you know, there are other measures. But the fact is, is that when

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