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Mad in America: Rethinking Mental Health

Mitochondria and Energetic Failures - A New Understanding of Antidepressant Withdrawal? An Interview with Chris Masterjohn

Mad in America: Rethinking Mental Health

Mad in America

Mental Health, Medicine, Health & Fitness

4.7212 Ratings

🗓️ 21 January 2026

⏱️ 44 minutes

🧾️ Download transcript

Summary

This week, we are joined by Chris Masterjohn, PhD. Chris is a nutritional scientist, a former professor, and the founder of Mitome. With a PhD in nutritional science and years of research in mitochondrial biology, Chris's work focuses on translating peer-reviewed science into practical tools for human health.

At Mitome, Dr. Masterjohn pioneered the first analysis designed to measure mitochondrial respiratory chain function directly, identifying individual energy bottlenecks and guiding personalized science-backed protocols to optimize the system responsible for over 90% of cellular energy production. His mission is to bring mitochondrial testing out of the rare disease space and into everyday health.

In this interview, we discuss why so little is understood about the role serotonin plays in the body and how our mitochondria might play a part in the experince of antidepressant withdrawal.

***

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Transcript

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0:00.0

Welcome to the Madden America Podcast, your source for science, psychiatry, and social justice.

0:15.2

Welcome to the Madden America podcast. My name is Brook Seam, and I am the author of the award-winning

0:20.0

memoir on antidepressant

0:21.2

withdrawal may cause side effects. Today I am so excited because I am with Chris Masterjohn PhD.

0:27.6

Chris is a nutritional scientist, former professor, and founder of mitome. With a PhD in nutritional

0:33.2

science and years of research in mitochondrial biology, Chris's work focuses on translating

0:38.4

pure-reviewed science into practical tools for human health. At Mitome, Dr. Master John pioneered

0:44.5

the first analysis designed to measure mitochondrial respiratory chain function directly,

0:49.3

identifying individual energy bottlenecks and guiding personalized science-backed protocols

0:53.8

to optimize the system

0:55.2

responsible for over 90% of cellular energy production. His mission is to bring mitochondrial testing

1:01.4

out of the rare disease space and into everyday health. And all of this is going to connect to

1:06.9

his work around antidepressants in SSRIs, which is why I am specifically very excited to have

1:12.5

him here today. Chris, thank you so much for being here.

1:16.1

Thank you for having me. Great to be here.

1:18.4

So I started researching more of you and your work back over in the summer because I'd been

1:23.9

following you for a while and we had gone from talking a lot more about nutrition

1:28.7

to suddenly talking about SSRIs. And in my case, I was put on a combination of FXER XR and

1:36.2

Wobudron XL when I was 15 as a kid and my father had suddenly died. I was tossed on these drugs.

1:42.5

And then I was on those drugs, long with four others

1:45.1

for other side effects from the antidepressants for the next 15 years. And then I was suddenly

1:51.6

pulled off of them by a psychiatrist, which sent me into horrific antidepressant withdrawal.

...

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