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NutritionFacts.org Video Podcast

Melatonin Supplements for Sleep and Anti-Aging?

NutritionFacts.org Video Podcast

Michael Greger, M.D. FACLM

Alternative Health, Nutrition, Health & Fitness

4.8952 Ratings

🗓️ 12 February 2025

⏱️ 5 minutes

🧾️ Download transcript

Summary

The secretion of melatonin appears to progressively decline with age, dropping as much as 70 percent between middle and older age.

Transcript

Click on a timestamp to play from that location

0:00.0

Some experts recommend melatonin as a first-line agent to treat insomnia in older adults.

0:13.0

The world's sleep society disagrees due to its low efficacy. Subjectively, people report better sleep,

0:20.0

though objectively, a meta-analysis of studies found

0:22.6

that melatonin only helped people get to sleep four minutes faster and extended overall sleep

0:28.6

duration by about 13 minutes.

0:30.6

If you do want to try melatonin to help with sleep, older adults are advised to use the smallest

0:35.6

effective dose, an hour before bedtime, starting

0:39.2

perhaps at 0.3 milligrams.

0:42.2

The 12 milligrams supplements on the market could produce levels in the bloodstream that can

0:46.0

be 200 times higher than normal nightly levels, which raises safety concerns.

0:52.3

After all, melatonin used to be known as the anti-gonad hormone,

0:56.0

with humanocleven doses of just a milligram or two,

0:59.0

reducing the size of sex organs and impairing fertility in laboratory animals.

1:04.0

Furthermore, due to poor regulation of dietary supplements,

1:08.0

in the U.S., you never know what you're going to be getting.

1:12.6

An analysis of 31 different brands of melatonin supplements found that the actual melatonin

1:17.8

content varied up to nearly 500% compared to what was listed on the bottle.

1:23.4

Even within a single brand, different lots of the same product suffered similar variability.

1:30.3

Given that there's no guarantee of the strength or purity of melatonin supplements,

1:34.3

many countries have banned over-the-counter melatonin,

1:38.3

making it prescription only so authenticity could be ensured.

1:43.3

U.S. citizens can get certified melatonin by sending a prescription to an online Canadian

...

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