May 10 2024 This Week in Cardiology

This Week in Cardiology

Medscape Podcasts

Medicine, Science, Health & Fitness

4.9 • 963 Ratings

🗓️ 10 May 2024

⏱️ 32 minutes

🔗️ Recording | iTunes | RSS

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Summary

Inclisiran, sodium-channel blocker safety, analytic flexibility, the work-up of patients with HF, and BP in older patients are the topics John Mandrola, MD, covers in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Inclisiran Update

ORION 4 https://classic.clinicaltrials.gov/ct2/show/NCT03705234

II. Sodium-Channel AADs

UPenn Paper https://doi.org/10.1016/j.jacep.2024.01.021
Three Questions Editorial https://www.ahajournals.org/doi/full/10.1161/circoutcomes.110.957381
EAST Post-hoc Review https://doi.org/10.1093/europace/euae121

III. Analytic Flexibility

Is Red Meat Healthy? Multiverse Analysis Has Lessons Beyond Meat

https://www.medscape.com/viewarticle/red-meat-healthy-multiverse-analysis-has-lessons-beyond-meat-2024a10008qv

Specification Curve Analysis of Red Meat Data https://doi.org/10.1016/j.jclinepi.2024.111278

IV. The Work-up of Patients With HF

Durstenfeld and colleagues, UCSF https://www.ahajournals.org/doi/abs/10.1161/CIRCOUTCOMES.123.010800
REVIVED BCIS2 https://www.nejm.org/doi/full/10.1056/NEJMoa2206606

V. BP Therapy in Older Patients

Haring and colleagues; Women's Health Initiative BP Study https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.067302
SPRINT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1511939

You may also like:

The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net

Transcript

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0:00.0	You're listening to this week in cardiology from the heart
0:03.4	org medscape cardiology this podcast is intended for health care
0:07.6	professionals only any views expressed are the presenters own and do not
0:11.2	necessarily reflect the views of WebMD or Medscape.
0:15.1	You can now access the latest in medical news on your Amazon Alexa-enabled device.
0:19.7	Join me, Perry Wilson, every weekday morning for Medscape Medical Minute where I highlight the top
0:24.7	medical stories of the day.
0:26.5	To add Medscape Medical Minute to your flash briefing, search for Medscape Medical
0:30.1	Minute on Amazon and click enable or open the Amazon Alexa app go to skills search for
0:35.6	Medscape Medical Minute and click enable then say Alexa what's the news or
0:40.6	Alexa what's my flash briefing I hope you'll join us.
0:44.0	Hi everyone this is John Mandrola from the Heart.org Medscape cardiology and this is
0:50.2	this week in cardiology for May 10th, 2024.
0:54.5	This week, I'll do an Enclisseran update.
0:58.7	How Dangerous Are sodium Channel Blocking Anti-Arhythmic Drugs? Analytic Flexibility and Stuff. channel blocking anti-arithmic drugs, analytic flexibility in studies, the workup of
1:06.5	patients with heart failure, and blood pressure in older patients.
1:12.2	First some reader feedback on Enclisserant. Last week I discussed this drug a small
1:17.2	interfering RNA that inhibits PCSK9 production. The trial I discussed was Victorian and initiate and it was an RCT of using
1:26.1	enclisaran to get to a goal-LDL cholesterol. This was clearly a marketing disguised as science trial.
1:34.0	I bemoaned the fact that the drug gained FDA approval without a cardiovascular outcomes trial.
1:40.0	But many listeners wrote in to tell me about Orion 4, a 15,000 patient trial of
1:45.2	Enclisseran versus placebo in patients with established heart disease and a
	...

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