Mar 21 2025 This Week in Cardiology

This Week in Cardiology

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Cardiology, Science, Medicalpractice, Electrophysiologist, Medscape, Internalmedicine, Medicaldecisionmaking, Expertcommentary, Eartrhythmdisorder, Health, Perspective, Medicine, Healthnews, Medicalexpert, Endoflifecare, Clinicaltrials, Health & Fitness

4.9 • 876 Ratings

🗓️ 21 March 2025

⏱️ 28 minutes

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Summary

A large trial in cardiac pacing finally published, PVCs and cardiomyopathy, cannabis, CV risk and the danger of observational studies, and the tale of two disparate statin trials are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I BioPace Trial

Trial manuscript https://doi.org/10.1093/europace/euaf029

II Another Belief Challenged in EP this week—PVCs and CM ‘

UC Paper https://doi.org/10.1016/j.jacep.2025.01.004
JACC Review https://doi.org/10.1016/j.jacc.2024.03.416
Lee et al https://heart.bmj.com/content/105/18/1408

III Cannabis and CV Risk

Cannabis and MACE in JACC Advances: https://www.jacc.org/doi/10.1016/j.jacadv.2025.101698
Zeraatkar –Grilling the data https://doi.org/10.1016/j.jclinepi.2024.111278
PLOS-1 10.1371/journal.pone.0199705

IV Cardio-oncology

Jacc Onc Substdy https://www.jacc.org/doi/10.1016/j.jaccao.2024.11.008
Editorial https://www.jacc.org/doi/10.1016/j.jaccao.2025.01.006
STOP CA JAMA 2023 https://jamanetwork.com/journals/jama/fullarticle/2807988
PREVENT https://evidence.nejm.org/doi/10.1056/EVIDoa2200097

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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

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Transcript

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0:00.0	You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology.
0:05.8	This podcast is intended for health care professionals only.
0:08.8	Any views expressed are the presenters own and do not necessarily reflect the views of WebMD or Medscape.
0:15.0	Hi, everyone.
0:16.3	This is John Mandrola from the heart.org medscape cardiology, and this is this week in
0:21.4	cardiology for March 21st, 2025. This week, a big trial in cardiac pacing has finally been
0:29.8	published, PVCs in cardiomyopathy, cannabis, cardiovascular risk, and the danger of observational
0:37.2	studies, and finally, the tale of two
0:40.1	disparate statin trials. First up is the biopace trial. The Europace journal has published
0:48.0	the results of the biopace trial. First presented at the 2014 ESC meeting in Barcelona. The trial compared by v pacing versus standard
0:57.7	RV pacing in patients who had bradycardia and who would require lots of RV pacing. Biopase was
1:05.1	basically a preventive trial, the idea being that standard RV pacing does fix the bradycardia, yes, but
1:13.5	RV-paced beats create dysynchrony, much like a left bundle branch block, and that can induce
1:19.5	pacing-induced left-and-trigger dysfunction in a certain but highly debated number of patients.
1:26.6	But bivapacing is harder. It requires a third CSLV lead.
1:32.5	The question biopaste trial tested is whether the preventive, more synchronous biv pacing
1:37.7	would lead to better outcomes than the old standby, the single RV pacing lead.
1:43.6	It was a multi-center RCD conducted more than 20 years ago,
1:47.5	first started randomizing patients in 2003. This was 1,800 patients that randomized to either of the two
1:55.3	pacing strategies. The primary endpoint were two, death or heart failure hospitalization, and second co-primary survival time.
2:04.0	These patients were typical bradycardia pacing patients in their 70s.
2:08.8	About 90% RV pacing at one month, so they did pace a lot.
	...

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