Lose Fat as Your Metabolism Changes with Age
High Intensity Health with Mike Mutzel, MS
Mike Mutzel
4.8 • 1.2K Ratings
🗓️ 1 July 2023
⏱️ 22 minutes
🧾️ Download transcript
Summary
Let's discuss ways to prevent fat gain with age, focusing specifically on age-related hormonal and metabolic changes as well as fat cell physiology.
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Show Notes:
01:00 There are cellular changes within adipose tissue and skeletal muscle linked with aging.
01:47 As fat cells get older, they hold fat more tightly.
01:55 There is infiltration of immune cells within fat tissue.
02:35 Mitochondrial function decreases with aging.
03:00 Exercise purges senescent cells.
03:50 Serum DHEA decreases with age.
04:52 Hormonal changes in aging cause fat cells to misbehave leading to metabolic derangement.
08:45 Reduced testosterone and DHEA effect post meal fat storage in men.
09:40 Your upper body is more sensitive to storing lipids after a meal but can become overfilled.
10:30 Fat tissue inflammation can be linked to reduced physical activity.
11:12 As you get older and stop exercising, decrease protein, your fat cells become infiltrated and enlarged.
12:25 The more body fat you have, the more proinflammatory immune cells you have within your fat tissue.
13:20 Overfilled fat cells cause muscle cells to onboard more fat.
14:00 Physical training has a huge impact on preserving muscle protein synthesis.
15:50 Exercised muscles become more sensitive to nutrients.
16:30 Increase your protein intake as you get older.
17:30 Protein intake should be between 1.2 and 1.5. Grams per kilo of ideal bodyweight per day.
18:10 Fast twitch muscle fibers are preferentially lost with aging.
Transcript
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| 0:00.0 | A new paper highlights why you gain fat around the midsection as you age. |
| 0:03.4 | We're going to talk all about hormones and the changes within the fat cell as you age, |
| 0:07.6 | and what you can do about it. |
| 0:08.9 | I know many of you don't want to gain fat around the middle as you age. |
| 0:11.2 | You want to look like you did when you were in your teens or your early 20s. |
| 0:14.8 | Now, hopefully this paper and this article will help you better understand the things |
| 0:17.9 | that you can do right now to prevent age-related fat gain around the middle. |
| 0:21.4 | We're going to talk specifically about men and postmenopausal women. |
| 0:24.7 | It turns out that after menopause, women experience many hormonal changes that are linked |
| 0:28.7 | with metabolic changes within the fat tissue, and I want to share it to you insights and |
| 0:32.3 | practical takeaways that you can implement to offset some of those age-related changes. |
| 0:36.8 | The title of the paper that we're going to talk about today is metabolic changes in aging |
| 0:39.9 | humans, current evidence and therapeutic strategies. |
| 0:42.5 | This was published in the Journal of Clinical Investigation. |
| 0:45.2 | It's important to recognize this was not a randomized clinical trial. |
| 0:48.5 | This paper is looking at all the dossier of literature showing the age-related changes |
| 0:52.8 | within muscle tissue, fat tissue, and hormones that are linked with fat gain and fat-related |
| 0:57.9 | changes in changes within the fat cell itself. |
| 1:00.9 | As you can see here on Figure 2, there are cellular changes within adipose tissue and |
| 1:05.8 | skeletal muscle that are linked with aging. |
| 1:08.1 | I want to talk about some of the complex biology here and then finish up with the practical |
| 1:13.6 | tips and takeaways. |
... |
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