Hello and welcome to the Zero to Finals podcast.

My name is Tom and in this episode I'm going to be talking to you about Lambert Eton Myasthenic Syndrome.

And you can find written notes on this topic at zero to finals.com slash lambat Eton

or in the neurology section of the second edition of the zero to finals medicine book.

And you can find flashcards and questions to train your knowledge

and help you remember the information for longer at members.02finals.com.

So let's get straight into it.

Lambert Eaton Myasthenic Syndrome is an autoimmune condition affecting the neuromuscular junction, which is the connection between the motor neurons and

the muscles. In some ways, it's similar to myasthenia gravis, however the symptoms tend to be more

insidious and less pronounced than myasthenia gravis, however the symptoms tend to be more insidious and less pronounced than

myasthenia gravis. In most cases, it's a para neoplastic syndrome occurring alongside small cell lung

cancer. However, it can occur as a primary autoimmune disorder without the presence of small cell lung

cancer.

Let's start with the pathophysiology.

Lambertitin Myasenic syndrome results from antibodies that are created against voltage gated

calcium channels and these antibodies are produced in response to small-cell

lung cancer cells that also express voltage-gated calcium channels.

The immune system recognizes the small-cell lung cancer and produces antibodies.

These antibodies target and damage voltage-gated calcium channels in the pre-synaptic membrane

of the neuromuscular junction.

Voltage-gated calcium channels are responsible for assisting in the release of acetylcholine

into the synapse of the neuromuscular junction.

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