Kyle Shanahan previews 49ers' season opener, Christian McCaffrey listed as questionable

49ers Talk: A San Francisco 49ers Podcast

NBC Sports Bay Area

Nfl, Football, Matt Maiocco, San Francisco 49ers, Sports

4.6 • 988 Ratings

🗓️ 6 September 2025

⏱️ 44 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Matt Maiocco speaks with San Francisco 49ers coach Kyle Shanahan about their Week 1 matchup vs. the Seattle Seahawks and why he's optimistic about Christian McCaffrey's health despite the star running back being listed as questionable for Sunday's game. Greg Papa also joins to provide an encouraging update on his cancer battle.

Transcript

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0:00.0	Savings. Big O savings.
0:03.5	Get up to $120 in savings on select Michelin Tires with installation purchase.
0:09.0	Plus, zero interest if paid in full within 12 or six months.
0:13.1	Big O Tires, the team you trust.
0:19.4	The 49ers world was turned upside down on Thursday evening, with news that Christian McCaffrey had landed on the injury list with a calf condition.
0:30.4	Of course, that brought back bad memories of last season when he missed the first eight games with Achilles tendonitis in both legs.
0:38.0	That injury was originally listed in the summer of 2024 as a calf injury.
0:44.1	On this bonus episode of 49ers talk, Christian McCaffrey discusses his condition with an encouraging update.
0:51.5	We'll also hear from Coach Kyle Shanahan for his weekly 49ers game plan interview.
0:56.7	And we have a special treat. The voice of the 49ers Greg Papa opens up about his courageous
1:02.9	battle with cancer. You'll love Papa even more than you already do as he shares his inspiring message.
1:10.5	Thank you for tuning into this episode of 49ers talk coming at you right now.
1:15.5	Welcome to another episode of 49ers talk on NBC Sports Bay Area.com.
1:21.7	Introducing your hosts, Matt Mayoko and Jennifer Lee Chan.
1:26.0	All right, drive away knowing you got the best deal on the road with Big O' Tires Low Price Guarantee.
1:32.1	Check out this week's specials and set an appointment at Bigotires.com.
1:37.6	Bigotires, the team you trust.
1:40.6	And welcome to this bonus episode of 49ers talk and we have a lot to discuss including
1:47.2	after Jennifer and I and Jennifer heading up to Seattle for week one 49ers against the Seattle
1:53.9	Seahawks while I'm remaining back in the Bay Area for my new duties on 49ers pregame show and
2:00.2	post game show on NBC Sports Bay Area.
2:02.3	But when Jennifer and I both last taped 49ers talk, it was right before Joanne Jennings had
	...

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