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49ers Talk: A San Francisco 49ers Podcast

Kyle Shanahan, Greg Papa discuss 49ers’ Week 16 matchup vs. Colts, San Francisco controlling its own playoff destiny

49ers Talk: A San Francisco 49ers Podcast

NBC Sports Bay Area

Matt Maiocco, San Francisco 49ers, Football, Nfl, Sports

4.6988 Ratings

🗓️ 21 December 2025

⏱️ 53 minutes

🧾️ Download transcript

Summary

“49ers Talk” host Matt Maiocco provides the latest injury updates before speaking with coach Kyle Shanahan about San Francisco's Week 16 matchup vs. the Indianapolis Colts. Also, Greg Papa joins Matt to discuss how the Los Angeles Rams’ Week 16 loss to the Seattle Seahawks opens the door for the 49ers to capture the NFC West and the NFC's No.1 playoff seed.

Transcript

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0:00.0

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0:08.4

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0:17.1

The Seattle Seahawks victory over the LA Rams on Thursday night means two teams in the

0:27.4

NFC West control their own destinies. The Seahawks took a one-game lead on the Rams, and if they

0:33.0

went out, they will be the top seed in the NFC. And of course, there's the San Francisco 49ers. But first,

0:40.3

the 49ers have to take care of business with a victory on Monday night, and then the rest of the

0:45.0

way, they would control their own destiny too. We'll check in with Coach Kyle Shanahan to get you

0:50.5

set for this matchup against Philip Rivers, Jonathan Taylor, DeForest Buckner,

0:55.1

and the rest of the Indianapolis Colts. We'll also then get an amazing update from the voice

1:00.8

of the 49ers Greg Papa, who is nearing a return to the broadcast booth. We'll have all that

1:06.2

and much more on this episode of 49ers talk coming at you right now welcome to another episode of 49ers talk

1:14.2

on nbc sports bay area dot com introducing your hosts matt mayoko and jennifer lee chan all right

1:22.6

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1:36.7

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1:40.1

All right, Jennifer Lee Chan is en route to Indianapolis, where the 49ers and the Colts meet on Monday night football.

1:48.1

Colts are on a four-game losing streak.

1:50.3

The 49ers on a four-game winning streak.

1:53.1

And so this is a very important game for both teams.

1:56.0

And, of course, the storyline, Philip Rivers, Old Man Rivers at 44 years old, a father of 10 and a grandfather

...

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