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Azeem Azhar's Exponential View

Karpathy’s autoresearch could make scientists of us all

Azeem Azhar's Exponential View

EPIIPLUS 1 Ltd / Azeem Azhar

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5.01.1K Ratings

🗓️ 1 April 2026

⏱️ 21 minutes

🧾️ Download transcript

Summary

Published in early March 2026, Andrej Karpathy's autoresearch AI tool makes autonomous scientific experimentation cheap and easy — but it was designed to solve machine learning problems. I wanted to see if I could apply its loop architecture to my own work: refining my worldview, testing arguments, solving business problems.  In this video, I share how I adapted Karpathy’s autoresearch loops for problems that aren't easy to quantify, how to avoid the local minima trap, and the broader impact of these kinds of methods. I covered:

Transcript

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0:00.0

Today, I wanted to talk about a little tool that I came across about a month ago that has

0:04.4

really changed the way that I do some of my work. And that was a tool released by Andre

0:10.3

Carpathie. Now, what did Carpathie release? He released this thing called Auto Research. It's a

0:16.1

piece of open source software. It's only 600 lines of Python code. It's already had 57,000 stars on GitHub.

0:24.2

And what auto research does is it enables AI systems and you running an AI system to automatically

0:32.7

conduct research. I said, look, this could probably work outside of the machine learning domain. Could we

0:41.3

find some other way of defining the objective, right? Why does it have to be the loss function in an

0:47.8

ML product? Couldn't we define a business objective? So my new setup is this new version of auto research.

0:57.0

And what that allows me to do is run this iterative loop, this scientific loop,

1:02.0

hypothesis-driven testing automatically on all sorts of commercial, intellectual,

1:08.1

academic, theoretical, theoretical problems that are relevant for us.

1:11.3

This is a reduction in the cost of the scientific method.

1:15.0

You know, I'm applying this scientific method now to questions that benefit from it

1:19.3

where it would have been too expensive previously.

1:22.4

And science is the best method we have found for producing knowledge.

1:26.8

And we have given that method now to

1:29.5

LLMs at very, very low cost, and I get to choose what they investigate.

1:35.2

Well, I mean, for now.

1:43.1

I want you to zoom back and understand what this is about.

1:49.0

This is about addressing the best strategy that we as humanity have for producing knowledge.

1:56.0

That strategy is called science.

1:59.0

And science is the act of coming up with some kind of hypothesis

...

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