July 25 2025 This Week in Cardiology

This Week in Cardiology

Medscape Podcasts

Cardiology, Science, Medicalpractice, Electrophysiologist, Medscape, Internalmedicine, Medicaldecisionmaking, Expertcommentary, Eartrhythmdisorder, Health, Perspective, Medicine, Healthnews, Medicalexpert, Endoflifecare, Clinicaltrials, Health & Fitness

4.9 • 876 Ratings

🗓️ 25 July 2025

⏱️ 31 minutes

🔗️ Recording | iTunes | RSS

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Summary

The VENTOUX study of endurance athletes, the 10,000 step myth was not busted, rate vs rhythm control for AF, and GLP1 drugs and observational studies are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I Endurance Athletes and Arrhythmia (again)

VENTOUX trial

https://www.ahajournals.org/doi/10.1161/CIRCIMAGING.125.018470

II Daily Step Count and Health — no myths were busted.

Lancet Public Health: https://doi.org/10.1016/S2468-2667(25)00164-1

III Rate vs Rhythm Control of AF

Medscape: Everyone Deserves a Shot at the American Dream: Sinus Rhythm

https://www.medscape.com/viewarticle/everyone-deserves-shot-american-dream-sinus-rhythm-2025a1000jle

This Week in Cardiology, July 11, 2025 https://www.medscape.com/viewarticle/1002704
AFFIRM trial https://www.nejm.org/doi/full/10.1056/NEJMoa021328
AFFIRM substudy https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/486560

IV GLP-1 Drugs and Observational Studies

Neurodegeneration and Stroke After Semaglutide and Tirzepatide

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2836412

SUSTAIN-6 https://www.nejm.org/doi/full/10.1056/NEJMoa1607141
SELECT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307563

You may also like:

The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact [email protected]

Transcript

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0:00.0	You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology.
0:05.7	This podcast is intended for health care professionals only.
0:08.8	Any views expressed are the presenters' own and do not necessarily reflect the views of WebMD or Medscape.
0:15.8	Hi, everyone.
0:17.3	This is John Mandrola from the Heart.org Medscape Card cardiology and this is this week in cardiology for July 25th,
0:25.4	2025. This week, the Ventu study of endurance athletes, the 10,000 step myth was not busted, rate versus rhythm
0:36.8	control for atrial fibrillation, and GLP1 drugs and observational
0:42.5	studies. The first off is the Ventus study. The group at the University of Leeds have published
0:49.8	an interesting paper on endurance athletes, cardiac fibrosis, and ventricular arrhythmias.
0:56.3	They cheekily named it the Ventu study to correspond with a recent Tour de France stage
1:01.1	that finished on Mont Ventou this week. Now I've climbed Ventou. It took me one hour and
1:08.0	42 minutes. Taday and Jonas did it this week in 54 minutes, a record by a minute.
1:15.1	Now imagine liking, no loving, the notion of climbing a 10% gradient for well more than an hour,
1:22.6	and you will understand the mindset of older endurance athletes, which is relevant to this study.
1:29.2	Thinking that this sort of exercise is fun is sort of a disease. People who do this day in
1:35.8	and day out for decades have an affliction. I know because I do. We're like rodents who, when
1:42.8	given a wheel in our cage, will run on it for no purpose
1:47.1	other than to just run on it. Now, before I say anything else, I want to start with the fact that
1:53.5	exercise is one of the pillars of health. It's in every expert consensus document, and there
1:59.4	are oodles and oodles of observational studies
2:02.1	that correlate exercise with survival and longevity.
2:07.9	But 60-year-old people who cycle or run more than 10 hours per week for decades are not
	...

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