Aug 01 2025 This Week in Cardiology

This Week in Cardiology

Medscape Podcasts

Cardiology, Science, Medicalpractice, Electrophysiologist, Medscape, Internalmedicine, Medicaldecisionmaking, Expertcommentary, Eartrhythmdisorder, Health, Perspective, Medicine, Healthnews, Medicalexpert, Endoflifecare, Clinicaltrials, Health & Fitness

4.9 • 876 Ratings

🗓️ 1 August 2025

⏱️ 30 minutes

🔗️ Recording | iTunes | RSS

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Summary

Exercise and CV outcomes, aldosterone modulation, AI for ECG reading, GLP-1 comparisons, end-of-life decisions, and another well-meaning policy that caused harm in veterans are discussed by John Mandrola, MD, in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I Exercise and CV outcomes

II Aldosterone Modulation in Cardio-Kidney Disease

Aldosterone and Aldosterone Modulation https://doi.org/10.1016/j.jacc.2025.06.012
Randomized Aldactone Evaluation Study https://www.nejm.org/doi/full/10.1056/NEJM199909023411001

III AI vs MD ECG-Reading for Cath Lab Activation

Accuracy of Cath Lab Activation Decisions https://doi.org/10.1016/j.ajem.2025.07.061

IV Tirzepatide vs Dulaglutide - SURPASS CVOT Study

Eli Lilly Press Release https://investor.lilly.com/news-releases/news-release-details/lillys-mounjaro-tirzepatide-gipglp-1-dual-agonist-demonstrated
REWIND Study 10.1016/S0140-6736(19)31149-3 External Link

V End-of-Life Decisions

Doctors’ Own End-of-Life Choices Defy Common Medical Practice

https://www.medscape.com/viewarticle/doctors-own-end-life-choices-defy-common-medical-practice-2025a1000k01

Physicians’ Preferences for Their Own End of Life https://jme.bmj.com/content/early/2025/06/05/jme-2024-110192
How US Doctors Die: A Cohort Study https://agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/jgs.14112

VI Well-Meaning Policies That Make Sense

The Mission Act and Cardiovascular Procedures https://jamanetwork.com/journals/jama/fullarticle/2837067

You may also like:

The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact [email protected]

Transcript

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0:00.0	You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology.
0:05.7	This podcast is intended for health care professionals only.
0:08.8	Any views expressed are the presenters' own and do not necessarily reflect the views of WebMD or Medscape.
0:14.6	Hi, everyone.
0:15.8	This is John Mandrola from the Heart.org, Medscape Cardiology, and this is this week in cardiology for August 1st,
0:23.5	2025. This week, exercise in cardiovascular outcomes, aldosterone modulation, AI for ECG reading,
0:33.4	GLP1 comparisons, end-of-life decisions, and yet another well-meaning policy that caused substantial
0:41.1	harm this time in U.S. veterans. First, listener feedback. My former partner, Anthony Pearson,
0:50.1	an ecocardiographer, super smart person, and blogger known as a skeptical cardiologist,
0:55.8	wrote to me about my comments last week on exercise. He wrote, quote,
1:02.0	I was shocked to hear you quote, major guidelines and numerous observational studies to support
1:06.6	the concept that physical activity lowers cardiovascular death, etc. I was even more shocked to hear you
1:12.9	discussed a 10,000 step study. Again, it's purely observational data as if the higher step counts
1:19.5	were reducing your CV death rate, etc. John, have you looked at the RCTs in this area? Why do you have such intense blinders on when it comes to critical analysis of the data supporting exercise and physical activity?
1:33.3	You don't have to answer. I know why.
1:36.3	The logic is that exercise is good. It's good for me. People should exercise more.
1:42.3	We can't possibly critique the epidemiologic data that establishes
1:46.0	the CB health benefits because that people might exercise less. At the very least, you should
1:52.1	throw in a limitation statement when quoting these types of study. Non-sedentarily yours, he signs.
1:59.2	I love this comment.
2:04.5	Indeed, the empirical evidence for exercise is weak to non-existent.
2:09.3	It would be nearly impossible to study lifelong exercise and cardiovascular outcomes.
	...

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