Journal Review in Transplant Surgery: Normothermic Machine Perfusion

Behind The Knife: The Surgery Podcast

Science, Health & Fitness, Medicine, Education

4.8 • 1.4K Ratings

🗓️ 12 January 2023

⏱️ 21 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this episode, our transplant team will discuss an article that reviews normothermic machine perfusion including how it has evolved over the years, current benefits and challenges, as well as future directions.

Learning objectives:
· Understand the current role of machine perfusion in renal transplantation
· Describe historical and current limitations of machine perfusion for abdominal organ transplantation
· Review the benefits of improved and expanded preservation techniques

References:
1. Hamelink, T. L., Ogurlu, B., de Beule, J., Lantinga, V. A., Pool, M. B. F., Venema, L. H., Leuvenink, H. G. D., Jochmans, I., & Moers, C. (2022). Renal Normothermic Machine Perfusion: The Road Toward Clinical Implementation of a Promising Pretransplant Organ Assessment Tool. In Transplantation (Vol. 106, Issue 2). https://doi.org/10.1097/TP.0000000000003817

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Transcript

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0:00.0	Behind the knife, the surgery podcast, relevant and engaging content designed to help you dominate the day.
0:14.0	Are you a passionate surgical educator with something to say, then join behind the knife and let the world hear.
0:29.0	Behind the knife is the number one surgery podcast in the world with each episode reaching 20,000 listeners.
0:34.0	Our current group of subspecialty teams have created incredibly diverse and engaging content.
0:39.0	But their commitments are nearly finished and we want to open up the opportunity to all of our listeners.
0:44.0	We're looking for teams of three to four surgeons who will develop one new subspecialty podcast every four months.
0:50.0	To learn more, check out the show notes or contact us at hello at BehindTheNife.org.
0:55.0	Applications are due February 13th.
0:57.0	Welcome to another episode behind the knife. I'm Megan Lombardi, a fourth-year general surgery resident.
1:02.0	I'm Sasha McEwan, a third-year general surgery resident.
1:05.0	I'm Gile Veda, one of the fifth-year general surgery residents.
1:08.0	I'm Alex Toledo, one of the transplant surgery attendings.
1:12.0	And I'm David Gerber, also one of the transplant surgery attendings here at the University of North Carolina.
1:17.0	Today we're going to be discussing a review article called renal, normal thermic machine perfusion.
1:23.0	The road toward clinical implementation of a promising pre-transplant organ assessment tool.
1:29.0	This review article was published in 2022 on transplantation by Tin Hamelink and colleagues from the Netherlands and Belgium.
1:37.0	The increased utilization of high-risk wino grafts for transplantation requires optimization of pre-transplant organ assessment strategies.
1:45.0	Current decision-making methods to accept an organ for transplantation lack overall predictive power and have some subjectivity.
1:53.0	Normal thermic machine perfusion or NMP creates a near-fusological conditions which might facilitate a more objective assessment of organ quality before transplantation.
2:04.0	It is rapidly gaining popularity with various transplant centers developing their own protocols and renal viability criteria.
2:13.0	However, to date, no validated sets of on-pump viability markers exist nor are there unified NMP protocols bringing the key question that needs to be answered to what to assess why Joaquin is on the pump.
2:29.0	Multiple parts are involved.
	...

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