Journal Review in Transplant Surgery: History and Challenges of Xenotransplantation

Behind The Knife: The Surgery Podcast

Science, Health & Fitness, Medicine, Education

4.8 • 1.4K Ratings

🗓️ 9 May 2022

⏱️ 21 minutes

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Summary

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Inspired by recent transplant surgery headlines, in this episode we briefly review the history and challenges of xenotransplantation. We discuss an article recently published in the American Journal of Transplantation describing the transplant of a porcine kidney into a human decedent model.

Learning Objectives
· Understand the timeline of xenotransplantation and its historical challenges
· Review a recent article that describes the transplantation of a genetically-modified porcine kidney into a brain-dead human model
· Discuss ongoing obstacles to successful xenotransplantation and next steps

References
Porrett, P. M., Orandi, B. J., Kumar, V., Houp, J., Anderson, D., Cozette Killian, A., Hauptfeld-Dolejsek, V., Martin, D. E., Macedon, S., Budd, N., Stegner, K. L., Dandro, A., Kokkinaki, M., Kuravi, K. v., Reed, R. D., Fatima, H., Killian, J. T., Baker, G., Perry, J., … Locke, J. E. (2022). First clinical-grade porcine kidney xenotransplant using a human decedent model. American Journal of Transplantation, 22(4). https://doi.org/10.1111/ajt.16930

Schlich, T., & Lutters, B. (2022). Historical perspectives on xenotransplantation. The Lancet, 399(10331). https://doi.org/10.1016/s0140-6736(22)00529-3

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Transcript

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0:00.0	Behind the Knife, the surgery podcast, relevant and engaging content designed to help you
0:12.0	dominate the day.
0:24.4	Calling all surgical education junkies behind the knife is looking to add two new fellows
0:29.1	to our team. We are thrilled to be adding these positions. We've got so much great content
0:33.6	in the pipeline that we don't even know to do with ourselves. I'm talking big-time projects
0:38.4	that are going to make a big impact on surgical education. We've got specialty oral board
0:43.2	review, medical student education, digital education research, and a trauma surgery video
0:49.6	atlas just to name a few. We're looking for a couple of enterprising surgical residents
0:54.9	to take the bull by the horns and spearhead one of these major projects not to mention
0:59.7	help with the podcast, video, and other ongoing exciting behind the knife goodness. We are
1:05.7	offering a two-year fellowship starting July 2022 and ending June 2024. Only residents
1:12.0	begin their two-year research time will be considered, and the residents' institutions
1:16.1	and the mentor must approve of this fellowship. Check out the show notes for the application
1:21.0	link. All applications are due May 25th. So welcome back to behind the knife for the UNC
1:28.2	transplant team here with another episode, and I'm Megan I'm one of the third-year residents.
1:33.3	I'm Sasha I'm one of the second-year residents. I'm Guy I'm one of the fourth-year residents.
1:38.6	I'm Alex Toledo one of the transplant surgery attendings and the surgical director of the
1:43.4	Katie transplant program. And I'm David Gerber one of the other transplant surgeons and the
1:49.3	chief of the division of transplantation. So today we're going to discuss a topic that's
1:54.0	recently made a lot of headlines, Zeno transplantation. So in January of this year,
1:59.3	a team from the University of Maryland transplanted a genetically modified pig heart into a
2:04.2	seventy fifty seven-year-old man. That patient unfortunately passed away two months after
	...

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