Journal Review in Thoracic Surgery: Adjuvant Treatment in Esophageal and GEJ Cancer

Behind The Knife: The Surgery Podcast

Science, Health & Fitness, Medicine, Education

4.8 • 1.4K Ratings

🗓️ 30 March 2023

⏱️ 25 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this episode, our team discusses the Checkmate 577 trial, the landmark paper which approved the use of nivolumab for adjuvant treatment of stage II & III esophageal & GE junction cancer. Listen as our team reviews the study population, methods and results of this trial & discusses its clinical application as well as potential areas of future research.

Learning Objectives:
-Review the staging and treatment of esophageal and GEJ cancer
-Discuss the population, methods, and results of the Checkmate 577 trial
-Understand the mechanism of action of nivolumab and the PD1 pathway
-Discuss the implications of the Checkmate 577 trial in clinical practice and areas of future research

Hosts:
Kelly Daus MD, Megan Lenihan MD, Peter White MD, and Brian Louie MD

Referenced Material
https://www.nejm.org/doi/full/10.1056/NEJMoa2032125
Kelly RJ, Ajani JA, Kuzdzal J, et al. Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer. N Engl J Med. 2021;384(13):1191-1203. doi:10.1056/NEJMoa2032125

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136921/
Han Y, Liu D, Li L. PD-1/PD-L1 pathway: current researches in cancer. Am J Cancer Res. 2020 Mar 1;10(3):727-742. PMID: 32266087; PMCID: PMC7136921.

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Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.

If you liked this episode, check out other thoracic surgery episodes here https://behindtheknife.org/podcast-category/cardiothoracic/

Transcript

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0:00.0	Behind the Night, the Surgery Podcast, relevant and engaging content designed to help you dominate the day.
0:23.0	Have you been working hard to dominate your surgical residency?
0:26.0	Do you want to help others to dominate no matter what stage of training they're in?
0:29.8	Hi to all of our BTK listeners. My name is Nina Clark, General Surgery resident at the University of Washington.
0:35.8	And I'm Jessica Mallard, General Surgery resident at the University of Michigan.
0:38.8	We both have had the privilege of working as behind the knife education college for the past year, and we're excited to continue growing our team.
0:45.8	Are you a surgical resident interested and enthusiastic about surgical education?
0:50.8	BTK is offering a two year surgical education fellowship starting July 1st, 2023 and ending June 30th, 2025.
0:58.8	Only residents who are starting a two year block, a professional development time away from full-time clinical activity will be considered.
1:05.8	And you have to ensure that your institution and mentor approve of this fellowship.
1:10.8	Fellows will be deeply involved in the BTK activities.
1:13.8	The two of us have worked on an absite revamp, not tying video series, our new trauma video atlas, and a comprehensive student resource just to start.
1:22.8	While this is an unpaid internship, you'll have access to the all of the behind the knife resources, like illustrators, editors, recording and video equipment, and more to help make high quality surgical education content.
1:34.8	Applications are due April 16th, and you can find the link to the application in our show notes or on our Twitter page at Behind the Knife.
1:42.8	You can also contact us at helloatbehindtheknife.org with any questions.
1:47.8	We've had a great time so far this year, and there's only more to come.
1:51.8	We hope you'll consider joining us.
1:53.8	Hello, and welcome back to another journal review in thoracic surgery with your Swedish Medical Center thoracic surgery team.
2:00.8	I'm Kelly Dawes, and today I'm joined by my beloved co-host, Dr. Megan Lennahan, and our esteemed attendings, Dr. Brian Louis and Dr. Peter White.
2:09.8	We are really excited to share with you this journal club today covering the Checkmate 577 trial, which changed the game in the Adjutant Management of a Sophagile and GE Junction Cancer.
2:19.8	We hope to share some stellar pearls regarding the treatment of a Sophagile cancer.
2:24.8	Comprehensively review this landmark trial, discuss the impact it's had, and where we go from here as we continue to make advances in the treatment of this challenging and aggressive cancer.
	...

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