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Behind The Knife: The Surgery Podcast

Journal Review in Hepatopancreaticobiliary Surgery: Surgical Outcomes of the SWOG S1505 Trial

Behind The Knife: The Surgery Podcast

Behind The Knife: The Surgery Podcast

Science, Health & Fitness, Medicine, Education

4.81.4K Ratings

🗓️ 18 October 2021

⏱️ 60 minutes

🧾️ Download transcript

Summary

Journal Review in HPB – Surgical Outcomes of the SWOG S1505 Trial

Description: Neoadjuvant chemotherapy remains a controversial topic for resectable pancreatic adenocarcinoma. This randomized trial examines surgical and clinical outcomes from peri-operative regimens, mFOLFIRNOX and gem-Abraxane. The HPB Behind the Knife team dives into the specifics of the trial design and findings, as well as sits down with the Principal Investigator Dr. Syed Ahmad himself to ask about the behind-the-scenes decision-making and the investigations yet to come.

Links to Papers Reviewed in this Episode

Surgical Outcome Results from SWOG S1505: A Randomized Clinical Trial of mFOLFIRINOX Versus Gemcitabine/Nab-paclitaxel for Perioperative Treatment of Resectable Pancreatic Ductal Adenocarcinoma
Ann Surg. 2020 Sep;272(3):481-486
https://pubmed.ncbi.nlm.nih.gov/32740235/

Efficacy of Periopertive Chemotherapy for Resectable Pancreatic Adenocarcinoma: A Phase 2 Randomized Clinical Trial
JAMA Oncol. 2021 Mar;7(3):421-427
https://pubmed.ncbi.nlm.nih.gov/33475684/

Guest:
Syed Ahmad, MD (@SyedAAhmad5) is a Professor of Surgery and Chief of the Division of Surgical Oncology at the University of Cincinnati College of Medicine, and the Director of the UC Cancer Center. He is the surgical chair of SWOG, and a co-Principal Investigator of the SWOG S1505 study in addition to numerous other national trials for pancreatic cancer.

Hosts:
Timothy Vreeland, MD, FACS (@vreelant) is an Assistant Professor of Surgery at the Uniformed Services University of the Health Sciences and Surgical Oncologist at Brooke Army Medical Center

Daniel Nelson, DO, FACS (@DWNelsonHPB) is an Associate Professor of Surgery at the Uniformed Services University of the Health Sciences and Surgical Oncologist at William Beaumont Army Medical Center

Connor Chick, MD (@connor_chick) is a PGY-4 General Surgery resident at Brooke Army Medical Center

Lexy (Alexandra) Adams, MD, MPH (@lexyadams16) is a PGY-3 General Surgery resident at Brooke Army Medical Center

Other References from this Episode

FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer
N Engl J Med. 2018 Dec 20;379:2395-2406
https://www.nejm.org/doi/full/10.1056/NEJMoa1809775

APACT: phase III, multicenter, international, open-label, randomized trial of adjuvant nab-paclitaxel plus gemcitabine (nab-P/G) vs gemcitabine (G) for surgically resected pancreatic adenocarcinoma
J Clin Oncol. 2019 May 20;37:no. 15 suppl:4000.
https://ascopubs.org/doi/10.1200/JCO.2019.37.15_suppl.4000

Operative Standards in Cancer Surgery: Pancreatoduodenectomy: Superior Mesenteric Artery Dissection
American College of Surgeons. 2020 Jun 18.
https://www.facs.org/quality-programs/cancer/acs-crp/oscs
https://www.youtube.com/watch?v=bs8xlCr5XyE

The AHPBA Podcast
The Americas Hepato-Pancreato-Biliary Association
https://podcasts.apple.com/us/podcast/the-ahpba-podcast/id1501441845

Please visit behindtheknife.org to access other high-yield surgical education podcasts, videos and more.

Transcript

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0:00.0

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garages and the car pickup services included. So since that's all handled, how about you

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head to fixter.co.uk. We'll pick up your car and take care of all the rest. Fixed up

0:28.8

and you'll back on track. Behind the knife, the surgery podcast, where we take a behind

0:34.2

the scenes intimate look at surgery from leaders in the field.

0:51.4

Hello, and welcome back to Behind the Knife. We're the hepato pink rattle delivery team,

0:55.8

and we're excited to bring you another HPB dedicated episode.

0:59.4

So for today's episode, we're going to be discussing an important paper from the field

1:02.7

of HPB. This paper comes out of the annals of surgery. This is a paper published in September

1:09.0

of 2020. The first author, Siamad, will be our guest for a later part of the podcast.

1:15.2

This article discussed the SWAG S-1505 trial, which examined the efficacy of perioperative

1:21.7

therapy for resectable pancreatic adenocarcinoma. There was another paper also published this

1:28.0

one in JAMA oncology, which will come up throughout the conversation as well. The first author

1:34.9

for that was Dr. Sohal, and that was published again in JAMA oncology in March of 2021.

1:41.0

So first we'll review the basics of the trial itself. Then in the second half, we mentioned

1:45.8

we'll talk to Dr. Aman, and hear what his impression of the trial results were.

1:52.5

For listeners, if you enjoy hearing from Dr. Aman and other giants of HPB surgery, we

1:57.6

would also encourage you to check out the HPB podcast as well, where you can hear Dr.

...

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