Journal Review in Colorectal Surgery: Anastomotic Healing, Leak and Gut Microbiome

Behind The Knife: The Surgery Podcast

Science, Health & Fitness, Medicine, Education

4.8 • 1.4K Ratings

🗓️ 1 May 2023

⏱️ 19 minutes

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Summary

Upon encountering a patient who develops an anastomotic leak after a straight-forward low anterior resection, you are taken aback, as the patient is healthy and has no apparent risk factors. This prompts you to consider whether the microbiota may have played a role in causing the leak.

Join Dr. Carole Richard, Dr. François Dagbert, Dr. Maher Al Khaldi, and Dr. Roy Hajjar in their conversation about the impact of gut microbiota on anastomotic healing and leak.

Learning objectives
- To list the known risk factors for anastomotic leak.
- To understand how preoperative gut microbiota influence anastomotic healing and could lead to leak.

Reference
Hajjar R, Gonzalez E, Fragoso G, et al. Gut microbiota influence anastomotic healing in colorectal cancer surgery through modulation of mucosal proinflammatory cytokines. Gut. Published Online First: 30 December 2022. doi: 10.1136/gutjnl-2022-328389

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Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.

If you liked this episode, check out other colorectal surgery episodes here: https://behindtheknife.org/podcast-category/colorectal/

Transcript

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0:00.0	Behind the Night, the Surgery Podcast, relevant and engaging content designed to help you dominate the day.
0:13.0	Bajoua from the colorectal surgery team from University of Montreal, Canada.
0:28.0	This is our last episode of the six-part series, special thank you to the behind-the-knife organizers
0:36.0	for having given us this opportunity of knowledge and passion sharing with you all listeners.
0:43.0	Hope our friend's accent was bearable and understandable.
0:48.0	I truly want to acknowledge the work and dedication that I resident Maya Pgy4 put into this project.
0:57.0	Thank you so much Maya and we'll go for drinks after.
1:02.0	Thank you for your guidance.
1:05.0	So for this last journal club from Montreal, we chose to present some of our work which was published in GUT.
1:13.0	Although it is fundamental research, it deals with microbiome and colorectal and asthmatic leak,
1:20.0	so we feel that the pertinence to clinical implication was interesting enough to bring this to this podcast, so hope you enjoy.
1:30.0	The article we will discuss today is entitled Gut Microbioda Influence and Asthmatic Healing in Colorectal Cancer Surgery
1:38.0	through modulation of mucosal pro-inflammatory cytokines published as Dr. Rishar said in GUT in December of 2022.
1:46.0	So we invited to discuss this paper, Roy Ajad, who's a PGY4, who's in fact finishing his PhD,
1:56.0	which focused on the relationship between Gut Microbioda and colorectal and asthmatic leak.
2:04.0	Roy is the first author on this publication.
2:07.0	We have a new Roy.
2:10.0	Thank you for having me. I'm very happy to be here.
2:13.0	Alright, so prior to diving you through the article, let's briefly talk about an asthmatic healing and leak,
2:19.0	a topic that forces all colorectal surgeons to stay humble, as it could happen to anyone, anywhere, and anytime.
2:27.0	There are just some factors related to an asthmatic healing that cannot be controlled or are not yet fully understood,
2:34.0	which is why we find a topic extremely important to cover.
	...

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