Journal Club With Dr. Peter Attia | Metformin for Longevity & the Power of Belief Effects

Huberman Lab

Scicomm Media

Science, Health & Fitness, Life Sciences

4.8 • 26.2K Ratings

🗓️ 11 September 2023

⏱️ 141 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this journal club episode, my guest is Stanford and Johns Hopkins-trained physician, Dr. Peter Attia, M.D., who is also the host of The Drive podcast and the author of the bestselling book "Outlive: The Science & Art of Longevity." We each present a scientific paper and discuss the findings' strengths, weaknesses and actionable takeaways. First, we discuss an article that addresses whether taking the drug metformin can enhance longevity. Then, we discuss an article on belief effects (similar to placebo effects), showing how the effects of a drug on the brain and cognition depend on one's belief about the dose of the drug taken, not the actual dose. Our conversation also highlights how to read, interpret and critique scientific studies. This episode ought to be of interest to those curious about health and longevity, medicine and psychology and for anyone seeking to better understand how to read and digest scientific findings. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Use Ask Huberman Lab, our new AI-powered platform, for a summary, clips, and insights from this episode. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Waking Up: https://wakingup.com/huberman Momentous: https://www.livemomentous.com/huberman Timestamps (00:00:00) Dr. Peter Attia, Journal Club (00:03:43) Sponsors: LMNT & Waking Up (00:06:11) Dreams (00:12:36) Article #1, Metformin, Mitochondria, Blood Glucose (00:19:47) Type 2 Diabetes & Causes, Insulin Resistance (00:25:30) Type 2 Diabetes Medications, Metformin, Geroprotection, Bannister Study (00:36:37) Sponsor: AG1 (00:37:15) TAME Trial; Demographics, Twin Cohort (00:44:27) Metformin & Mortality Rate (00:51:28) Kaplan-Meier Mortality Curve, Error Bars & Significance, Statistical Power (01:02:23) Hazard Ratios, Censoring (01:09:00) Metformin Advantage?, Variables, Interventions Testing Program (01:16:02) Berberine, Acarbose, SGLT2 Inhibitors (01:23:48) Blood Glucose & Energy Balance; Caloric Restriction, Aging Biomarkers (01:32:22) Tool: Reading Journal Articles, 4 Questions, Supplemental Information (01:38:10) Article #2, Belief Effects vs. Placebo Effect (01:45:22) Nicotine Effects (01:51:07) Nicotine Doses & Belief Effects, fMRI Scan (02:00:07) Biological Effects, Dose-Dependent Response & Belief Effects (02:05:14) Biology & Beliefs, Significance, Dopamine Response, Non-Smokers (02:10:57) Dose-Dependence & Beliefs, Side Effects, Nocebo Effect (02:19:06) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media Title Card Photo Credit: Mike Blabac Disclaimer

Transcript

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0:00.0	Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life.
0:06.0	I'm Andrew Huberman and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.
0:15.0	Today marks the first journal club episode between myself and Dr. Peter Attia.
0:20.3	For any of you that are not familiar with Dr. Peter Attia, he is a medical doctor and MD who is an expert in all aspects of health and lifespan, he is the author of a best-selling book entitled Outlive, which is a phenomenal resource on all things health span and life span. a
0:35.0	best-selling book entitled Outlive, which is a phenomenal resource on all things, health span and lifespan. And he is the host of the very popular podcast, The Drive,
0:39.0	where he interviews various experts in all domains of medicine and scientists as well.
0:44.8	Today Peter and I hold our first online collaborative journal club.
0:48.7	For those of you that aren't familiar with what a journal club is,
0:51.4	a journal club is a common practice in graduate school
0:54.1	and or medical school whereby students get together to discuss one or two papers
0:58.3	to critique those papers and to really compare their own conclusions of those
1:02.4	papers with the conclusions of the authors and to really compare their own conclusions of those papers
1:03.1	with the conclusions of the authors
1:04.7	and to highlight any key takeaways.
1:06.8	Peter and I have been wanting to do a journal club
1:08.6	together for a very long time,
1:10.8	and we decided to do that journal club and to record it for you. So today you will be sitting in on the first
1:16.9	Huberman Attia Journal Club, by the way it could just have easily been called the Attia
1:21.8	Huberman Journal Club, and we will discuss two papers.
1:25.1	First, Peter is going to discuss a paper on Metformin, which is a drug that many people are
1:31.1	interested in for its potential role in longevity. I want to
1:34.2	highlight potential there. He's going to compare that paper to previous findings on
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