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The a16z Show

John and Patrick Collison on Stripe's Growth, Agent Commerce, and the Future of Software

The a16z Show

a16z

Culture, Business, Science, Disruption, Technology, Software Eating The World, Entrepreneurship, Innovation

4.21.2K Ratings

🗓️ 28 April 2026

⏱️ 20 minutes

🧾️ Download transcript

Summary

This interview with Stripe cofounders John and Patrick Collison originally aired on TBPN. They discuss Stripe's 34% growth and new employee tender offer, how agent commerce and stablecoins may require high-throughput blockchains built for millions of transactions per second, and why the economics of software are shifting from mass-produced products to bespoke, on-demand systems cooked fresh at the moment of use.

Transcript

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0:00.0

The world is going to need platforms that support billions of transactions per second, billions of transactions per second, which no payment rail or platform does today.

0:11.5

Where we think things will go is just there will be a huge amount of agentic commerce.

0:16.5

And again, we're seeing a little bit of it today. We think there'll be a torrent of it.

0:20.2

And that is what unites stable coins in AI,

0:22.9

because we think you're going to need blockchains and better blockchains.

0:27.3

Up until now, the economics of software

0:29.5

have been conceived of it as fixed cost

0:32.1

and then infinitely monetize or monetize as much as possible.

0:35.5

That has these kind oftake-all dynamics.

0:37.9

But once there are inference costs and custom creation involved, it really shifts.

0:43.5

I mean, one executive who said, oh, yeah, we started, you know, augmenting our customer

0:47.8

service with AI so people are more productive, but we're just going to go back to doing it

0:51.3

the old-fashioned way.

0:53.4

Stripe processed more than a trillion dollars in payments last year.

0:56.8

It grew 34%.

0:58.3

And according to Patrick Collisome,

1:00.8

26Q1 may be looked back on as the first quarter of the singularity.

1:05.4

That's not a marketing line.

1:07.0

It's what the data is showing.

1:08.7

The 2025 cohort of businesses on Stripe is larger and performing better on a per-business basis than any prior cohort.

1:16.3

And the trend is accelerating.

1:18.6

In this conversation recorded live on TBPN, John and Patrick Cullison walk through what they're actually seeing in the real economy,

...

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