Jane Clarke on Protein Folding
The Life Scientific
BBC
4.6 • 1.4K Ratings
🗓️ 27 April 2021
⏱️ 29 minutes
🧾️ Download transcript
Summary
Professor Jane Clarke has had a fascinating double career. Having been a science teacher for many years, she didn’t start her research career until she was 40. Today she is a world-leading expert in molecular biophysics and, in particular, in how protein molecules in the body fold up into elaborate 3D structures, that only then enables them to carry out their roles. How they do this has been one of the fundamental questions in biology and the key to combating some of our most challenging diseases, caused by the misfolding of proteins.
Jane talks about her journey, from Tottenham schoolteacher to Cambridge Professor and Fellow of the Royal Society, and how, despite the obstacles she’s encountered along the way, she’s always been driven by her passion to understand the mystery of the machinery of life.
Producer: Adrian Washbourne
Transcript
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| 0:36.0 | Welcome to the podcast of the Life Scientific. |
| 0:39.5 | BBC Sounds, Music, Radio, Podcasts. |
| 0:43.4 | Professor Jane Clark has had a fascinating double career. |
| 0:47.3 | Having been a science teacher for many years, she didn't start her research career until |
| 0:51.1 | she was 40. |
| 0:52.1 | Today she's a world-leaning expert in molecular biophysics and in particular how protein |
| 0:58.4 | molecules fold up into elaborate three-dimensional structures. |
| 1:02.7 | There are millions of proteins inside every single cell in our body and they carry out most |
| 1:07.2 | of the functions necessary for life, so it's very important that we understand them. |
| 1:11.8 | However, simply knowing their chemical composition isn't enough, we also need to understand |
| 1:17.0 | their shape because that's what dictates how they work. |
| 1:20.9 | For decades how proteins fold in order to function has been one of the fundamental questions |
... |
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