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This Week in Startups

Is Anthropic Making the Biggest Mistake in AI History | E2258

This Week in Startups

Jason Calacanis

Technology

4.21.4K Ratings

🗓️ 5 March 2026

⏱️ 81 minutes

🧾️ Download transcript

Summary

This Week In Startups is made possible by:

Plaud - Plaud.ai/twist

LinkedIn Jobs - https://LinkedIn.com/twist.

Deel - https://deel.com/twist

Iru - https://iru.com/twist!


Today’s show:

It’s a packed TWiST Today! WITH US, we’ve got Erik Voorhees of VeniceAI and Logan Allin of Fin Capital on to talk agents, crypto, and… you guessed it, OPENCLAW!

Where does agentic AI meet the financial system? How will agents transact? And what does privacy look like in a world with omnipresent AI?

Stick around for some demos! We’ve got George Pickett to demo OpenClaw studio and David Kaufman to show us what he’s building at Siteline!


Timestamps:


00:04:31 What was Logan’s original thesis in Circle?


10:08 LinkedIn Jobs - Thanks to our partners at @LinkedIn! Post your job for free at https://⁠linkedIn.com/twist⁠ then promote it to get access to LinkedIn Jobs’ new AI assistant.


00:11:52 Logans thoughts on Open vs. Closed Source


00:15:33 How to maintain privacy in AI


20:02 Deel - Founders ship faster on Deel. Set up payroll for any country in minutes and get back to building. Visit https://⁠deel.com/twist⁠ to learn more.


00:23:29 Why LAUNCH’s token usage is trending higher than payroll!


00:25:05 How Fin capital uses personality types and AI to assess investments


00:29:45 Why Erik thinks Anthropic’s defiance of the federal gov. is bravery!


32:10 Iru - Iru unifies identity, endpoint security, and compliance into one platform. TWiST listeners get 20% off when they book a demo at https://⁠iru.com⁠/twist!


00:42:23 How Siteline is helping understand companies and their agent traffic.


00:57:15 OpenClaw Studio makes OpenClaw as user friendly as possible.


01:10:09 The layers and layers of Microstrategy’s business model.


01:11:44 Which AI tools are the most indispensable?


01:12:25 How Jason uses the Grok button on threads


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Follow Lon:

X: https://x.com/lons


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LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm


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LinkedIn: https://www.linkedin.com/in/jasoncalacanis


Check out all our partner offers: https://partners.launch.co/


Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland


Check out Jason’s suite of newsletters: https://substack.com/@calacanis


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Substack: https://twistartups.substack.com

Transcript

Click on a timestamp to play from that location

0:00.0

All right, everybody, welcome back to Twist.

0:01.9

It's March 4th, 2026.

0:05.6

Yeah, wow, I know.

0:07.0

Still sounds weird.

0:08.3

Still sounds weird.

0:09.1

But it is A.O.

0:11.7

39.

0:12.9

39.

0:15.9

This week in startups is brought to you by Eru.

0:19.1

Unify your identity, endpoint security, and compliance

0:22.4

into a single platform.

0:23.8

Book a demo at eru.com slash twist.

0:26.8

That's I-R-U.com slash twist.

0:30.1

Deal. Founders ship faster on deal.

0:32.5

Set up payroll for any country in minutes

0:34.6

and get back to building.

0:36.0

Visit deal.com slash twist to learn more and

0:39.9

LinkedIn jobs. Hire right the first time. Post your job and get $100 off towards your job post

0:46.0

at LinkedIn.com slash twist. 329 days after we first started talking about OpenClaught here.

0:57.2

It's been a full one month and one third.

0:59.6

And it is still sweeping through the internet.

1:05.0

It's become the number one, number one open source project in history, based on people following it.

...

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