Inserting human neurons into the brains of rats
Unexpected Elements
BBC
4.4 • 568 Ratings
🗓️ 16 October 2022
⏱️ 59 minutes
🧾️ Download transcript
Summary
Sergiu Pasca, Professor of Psychiatry at Stanford University has left the petri dish in the drawer and grown human neurons inside the brains of juvenile rats. Successful connectivity and brain function may allow for more rigorous testing and understanding of neurological conditions, that have until now remained difficult to localise and treat.
It’s been a few weeks since NASA’s DART mission smashed into an asteroid in an attempt to budge it off course, kickstarting Earth’s first planetary defence system. Scientists are starting to pour through the data to determine whether or not it worked. Dr Toney Minter, Head of Operations at Green Bank Observatory has been using Green Bank’s radio telescope to keep us updated and track the celestial system.
John Ryan, a Senior Research Specialist at Monterey Bay Aquarium Research Institute has spent the last three years studying the distinct vocal calls of blue whales. It’s part of a body of work that is unlocking the secretive existence of this endangered species, understanding how they react to the wind and search for food by navigating upwelling currents in the ocean.
Have you ever wondered what it would be like to live at the poles? Well, now you don’t have to imagine. Celas Marie-Sainte and Moreno Baricevic share their winterover experience, gathering data at the IceCube Neutrino Observatory in Antarctica. Hear what their work entails and ruminate on reflections of 6 months immersed in darkness.
And, One in every eight people live with a mental health disorder, so if that’s not you, it’s likely to be a close friend or family member. Despite there being a variety of known treatments, globally the majority of people suffering do not receive any medical support.
To see how the discussion around mental health is playing out across the African continent, CrowdScience visits Nairobi, Kenya. Presenter Marnie Chesterton is joined by a live audience and panel of experts - psychiatrist David Ndetei, psychotherapist Reson Sindiyo and mental health journalist Dannish Odongo - to get to the heart of what’s going on in our heads.
They discuss issues from taboo and superstition around mental health, to the treatment methods being used in Kenya that the rest of the world should know about.
(Image: Axial view of rat brain connectivity. Credit: Getty Images)
Presenter: Roland Pease Producer: Harry Lewis, Robbie Wojciechowski
Transcript
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| 0:00.0 | Oh, hello. You have chosen a BBC podcast, but before you listen to it, we thought you might |
| 0:04.7 | like our podcast too. You might. You might. It is called Sightracked with me, Nick Grimshaw. |
| 0:09.2 | And me, Annie Mack. And we talk about the week in music. All the news, all the cultural |
| 0:14.0 | happenings in the UK and beyond. And great guests. And it's on BBC Sounds. Yes, where you can |
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| 0:22.6 | live radio, everything from my six music breakfast show to Radio 3 Unwind. But obviously start |
| 0:29.2 | with our podcast, sidetrack. Obviously. Obviously. So if you like music, listen on BBC Sounds. |
| 0:34.0 | Thank you for downloading the Science Tower from the BBC World Service. |
| 0:42.9 | With me, Roland Bees and for CrowdSance Later in the podcast, the team has been to Nairobi to hear how mental health issues are tackled in Kenya, where this activist says even some of the |
| 0:48.7 | key words can be missing. I don't think in my own language we have a word for perhaps |
| 0:53.0 | schizophrenia or bipolar or ADHD. Depression. We don't have a word that defines it. We call it neko. Madness. That's what we call the spectrum of all mental illnesses. |
| 1:04.6 | Mental health issues in Kenya in half an hour. And it's the cell biology of mental health we're tackling on science and |
| 1:11.7 | action before that, with an extraordinary experiment with hybrid brains. Also, remember NASA's |
| 1:18.2 | DART mission to deflect an asteroid, which we featured only a few weeks back? Well, |
| 1:22.6 | it was dramatically successful. We have an update. We're also listening into Wales at dinner, |
| 1:29.8 | and we hear from the astronomers who spent winter at the South Pole. Despite my normally upright |
| 1:36.0 | intentions, I'm going to start with the single tabloid word Frankenbrain. That, in essence, |
| 1:43.8 | is what's been described in the journal Nature this week, |
| 1:47.4 | something of a brain hybrid consisting of a spot of human neural tissue grafted into the brain of a rat. |
| 1:54.5 | It's building on a decade or more of research using neurons, cultured in lab dishes, |
| 2:03.1 | in order to understand how brains work at the microscopic level, but hampered by the fact they don't develop very realistically. |
| 2:09.4 | The long-term aim is to understand and to treat mental illness better. |
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