All right, so welcome back to the Internet Book of Critical Care podcast. I'm here with

Adam Thomas, and we're going to talk about sodium channel blockade and tricyclic antidepressant

overdose. Yay! EKGs and talks! Yay! Josh, this is the fun one. We all get jacked up about TCAAs,

but it's few and far between

that I think we see TCA's now, but the sodium channel blockade is what we're really

concerned about with our pump no likey-likey the drugs that we took, right? Yeah, this is a challenging

topic to talk about because probably the most common form of sodium channel blocker intoxication

is tricyclic antidepressants.

So, like, most of what we know about sodium channel blockers is based on tricyclic

antidepressants.

But I think overall as a whole, it's better in some ways for us to think about this as

sodium channel blockers rather than tricyclics, because that prepares us for the diagnosis

and management of other various sodium channel blockers, which we may encounter.

But you put the best quote in there is that TCA's are the original gangster of sodium

channel blockade, right?

Yeah, I know. They taught us the fundamentals. And when you start looking into how other

sodium channel blocking drugs are treated, it's all based on tricyclic intoxication.

That's the basis. That's the rationale. That's the historical analysis.

Let's get into then the overview.

And then we'll talk about pathophys and more importantly, what does the EKG tell us and how do we manage it?

So let's start at the 360 view, big picture here.

What is going on with these agents and how do I see it on the EKG?

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