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The Dr. Gabrielle Lyon Show

How to Prevent Heart Disease with Mitochondria, Muscle, and the Endothelial Glycocalyx | Dr. Michael Twyman

The Dr. Gabrielle Lyon Show

Dr. Gabrielle Lyon

Medicine, Science, Health & Fitness, Life Sciences

4.6911 Ratings

🗓️ 8 July 2025

⏱️ 103 minutes

🧾️ Download transcript

Summary

Did you know every 40 seconds someone in the U.S. has a heart attack—and 1 in 5 never even see it coming? This week, I am joined by preventive cardiologist Dr. Michael Twyman as we discuss cutting-edge diagnostics, the endothelial glycocalyx, nitric oxide biology, and why muscle mass is your heart’s best friend. Learn the practical steps and questions to ask to protect your heart before symptoms appear.

Together, we explore:

  • Why silent heart attacks are so prevalent
  • The role of nitric oxide and the endothelial glycocalyx in vascular health
  • The critical link between muscle mass, VO₂ max, and heart resilience
  • How advanced imaging and testing are changing prevention
  • Debunking common myths around cardiovascular risk
  • Supplements and diagnostics Dr. Twyman uses to optimize cardiovascular health

This episode is a masterclass in heart disease prevention—don’t miss it.

Who is Dr. Michael Twyman

Dr. Twyman is a board-certified cardiologist specializing in early detection and prevention of cardiovascular disease. Founder of Apollo Cardiology in St. Louis, he’s recognized for integrating advanced arterial imaging, mitochondrial health strategies, and personalized medicine to optimize long-term heart health. Dr. Twyman’s mission is to educate his patients on how to live better and longer by optimizing their mitochondrial function to become heart attack proof.

This episode is brought to you by:


Find Michael Twyman at:


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Transcript

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0:00.0

Most people think heart disease starts with a bad cholesterol number. But the truth? The damage

0:06.4

often starts decades earlier, before you feel it, before you see it, and before your doctor catches it.

0:15.7

And once that early damage begins, it's silent, but it's not inevitable. You just need to know where to look

0:24.7

and what to do next. Most cardiologists don't talk about nitric oxide. They don't measure

0:31.1

VO2 max. They don't ask about grip strength or muscle mass, but they should because muscle is one of the most powerful

0:40.3

protectors of your heart and mitochondrial health. That might be the key to your entire

0:47.8

cardiovascular future. In today's episode, you'll learn why standard cholesterol labs are incomplete, how the loss of skeletal

0:57.4

muscle speeds up heart disease, what biomarkers matter more than LDL, and why diagnostics,

1:05.6

not guesswork, are the future of prevention. This is the medicine of what's possible. And my guest today is one of the

1:15.2

few cardiologists practicing it. Dr. Michael Twyman, expert in mitochondrial optimization, arterial

1:23.0

imaging, and a bio-individual, muscle-centric prevention approach. So if you could prevent a heart

1:32.2

attack before it starts, wouldn't you want to know how? Let's talk about what it really takes

1:38.8

to become heart attack proof with Dr. Michael Twyman. Dr. Michael Twyman.

1:49.3

Dr. Mike Twyman, welcome to the show.

1:50.5

Thank you for having me back.

1:53.4

Has it been 40 seconds yet?

1:54.8

Not yet.

1:55.2

Okay.

2:00.5

Well, as soon as it reaches 40 seconds, someone in the U.S. had a heart attack. And every 33 seconds, someone dies of cardiovascular

2:04.7

disease. It's a horrible stat. You know, it makes me think, how have we not gotten better at treating

2:13.7

that? I think we're getting there, but it's still the number one killer. You know,

2:18.2

we did this episode three years ago. Stats haven't changed that much since then. And I think we're

...

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