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Huberman Lab

How to Overcome Addiction to Substances or Behaviors | Dr. Keith Humphreys

Huberman Lab

Scicomm Media

Science, Life Sciences, Health & Fitness

4.830.3K Ratings

🗓️ 12 January 2026

⏱️ 207 minutes

🧾️ Download transcript

Summary

Dr. Keith Humphreys is a professor of psychiatry and behavioral sciences at Stanford School of Medicine and a leading expert on treating addictions, drug laws and policy. We discuss all the major addictive substances and behaviors, including alcohol, opioids, gambling, stimulants, nicotine, cannabis and more, focusing on how genetics and certain use patterns shape addiction susceptibility. We discuss the best evidence-based tools for recovery, from 12-step programs to emerging treatments such as psychedelics and ibogaine. Anyone interested in making better choices for their health and/or seeking to avoid or overcome addictions ought to benefit from this episode. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:00) Keith Humphreys (00:03:22) Addiction; Genetic Risk (00:09:14) Alcohol Use Disorder & Alcoholism; Genetic Predisposition & Addiction Risk (00:18:03) Sponsors: David & BetterHelp (00:20:37) Women & Alcohol Use; Young Adults; Cannabis Use (00:23:36) Health Benefit to Alcohol?, Red Wine, Cancer Risk; Social Pressure (00:31:47) Alcohol in Social Gatherings, Social Anxiety, Vulnerability, Work & Dates (00:37:41) Old vs New Cannabis & THC Levels; Smoked vs Edible Forms (00:44:38) Cannabis & Psychosis Risk; Cardiac Health; Youth Cannabis Use & Transition to Adulthood (00:52:29) Sponsor: AG1 (00:54:13) Industries of Addiction, Regulation; Gambling, Slot Machines, Novelty; Casinos (01:05:28) Decriminalization vs Legalization; Cannabis, Gateway Drug? (01:08:50) Psylocibin or LSD, Addiction Treatment; Microdosing, Clinical Trial Challenges (01:18:58) Sponsor: Helix Sleep (01:20:32) Brain Plasticity & Age; Ketamine, Depression, Transcranial Magnetic Stimulation (TMS) (01:28:10) SSRIs, Mass Shootings, Suicide, Side Effects; Drug Approval; Ibogaine & PTSD (01:36:10) Caffeine Addiction?; Stimulants & Rehab; Prescription Stimulants & ADHD (01:44:04) Nicotine, Mistaking Withdrawal for Benefit (01:47:24) Sponsor: LMNT (01:48:44) Tool: How to Talk to Someone with Addiction (01:55:23) Perception of Addicts, Character Defect, Pain (02:00:58) Overcoming Addiction, Immediate Rewards, AA; Addict & Co-Dependency? (02:09:53) Longterm Drug Use, Dopamine, Cues & Relapse; Social Media (02:16:21) Brain Stimulation, TMS; Homelessness, Substance Use & Rehab (02:26:11) Addiction Treatment Policy, Rehab & Insurance (02:29:08) Tool: 12-Step Programs, AA, Accessibility & Benefits (02:38:08) AA, Higher Power, Cult?; Flexibility, Tool: Open AA Meetings (02:44:38) GLP-1s, Weight Loss, Alcohol Addiction; Pharmaceutical Advertisements (02:52:39) Social Media Addiction, Tool: Avoiding Social Media Strategies (02:58:36) “Failure to Launch”, Youth, Video Games, Social Media; Recovery Pathways (03:04:13) AA as an Action Program, Tool: Try Different AA Meetings (03:08:21) Hospice, Death, Overcoming Fear of Death (03:13:54) Addiction to Escape Death?, Desire for Oblivion (03:18:11) Men vs Women & Addiction; Lying; Relapse; Fentanyl & Addiction Advice (03:24:27) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

Someone says, I want to quit smoking. A good clinician will say, why would you want to do that?

0:03.6

To say, so tell me, what would you want to? What do you want to get out of this? Because it's work. I mean, I'm happy to work with you, but what is it? What are your motives? And sort of helping them build up, you know, in their own mind, because again, this is about them, not you. What do you get? And that's what the therapist does.

0:20.4

The other thing is really important is that like any other, anytime you're making behavior

0:23.9

change, hang out with other people who are trying to make the same change. You want to start jogging, join a jogging group. You want to stop drinking. I would, you know, just go check into an AA meeting or one of the other fellowships we have. Having other people on the same journey is good for us. Everything shows that, no matter what you're doing, I'm losing late, I'm exercising, I'm more, whatever, I'm quitting, smoking, because it gives you two things. It gives you support, but it also gives you some accountability. Say, hey, you were going jogging. I mean, Tuesday, you weren't there. What's up? Are you going to be part of this group or not? And that is helpful for people. Welcome to the Huberman Lab podcast, where we discuss

1:00.9

science and science-based tools for everyday life. I'm Andrew Huberman, and I'm a professor

1:09.1

of neurobiology and ophthalmology at Stanford School of Medicine.

1:13.8

My guest today is Dr. Keith Humphreys.

1:16.2

Dr. Keith Humphreys is a professor of psychiatry and behavioral sciences at Stanford School of Medicine,

1:21.5

and he is one of the world's foremost experts on addictive substances and behaviors

1:25.5

and how to overcome addictions of all kinds.

1:28.5

He is also an expert on how science, commercial marketing, lobbying, and the legal system

1:33.1

interact to create what are called addiction for profit businesses. The alcohol, food, and opioid

1:38.4

industries come to mind as just a few examples of these, and he's an expert on how all of that

1:42.8

shapes things like legal policy.

1:45.1

Today, we discuss all the major addictions to give you the most up-to-date information on

1:49.8

alcohol, cannabis, opioids, gambling, and much more. Dr. Humphreys gives us the unbiased facts,

1:56.3

and more importantly, he explains how to think about the health risks of any substance or

2:00.7

behavior in a logical way. For instance, while it may be true that a importantly, he explains how to think about the health risks of any substance or behavior

2:01.1

in a logical way. For instance, while it may be true that a certain amount of alcohol could

2:06.2

afford you some heart health benefits, we hear this, then we hear it's not true, it goes back and

2:10.1

forth, he explains that any heart benefits that exist from alcohol are greatly offset by the increased

2:16.4

cancer and other risks of alcohol. And with respect

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