How to Get Microplastics Out of Your Body | Mara Labs : 1478
The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
4.6 • 7.4K Ratings
🗓️ 4 June 2026
⏱️ 69 minutes
🧾️ Download transcript
Summary
Sulforaphane, Detox Pathways, and the Science of Microplastic Removal
Microplastics are building up inside your brain, blood, and reproductive tissue, and most detox protocols do nothing to remove them. This episode gives you the cellular science behind why toxins accumulate, which three detox pathways control your ability to excrete them, and what the latest research shows actually moves microplastics, heavy metals, BPA, and benzene out of your body..
-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
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Host Dave Asprey sits down with Dr. John Gildea, a Johns Hopkins-trained PhD with 60 scientific publications and over 20 NIH-funded studies, and David Roberts, co-founder of Mara Labs and co-creator of BrocElite, the only naturally derived stable form of sulforaphane available in a capsule. Together they bring decades of research-backed biohacking and functional medicine insight into one of the most pressing longevity conversations of our time.
They break down the lysosome, your cell's built-in incinerator, and explain exactly why it gets clogged with microplastics, advanced glycation end products, and other toxins that won't break down. New research shows that sulforaphane triggers a process called lysosomal surface translocation, which releases those trapped particles so your body can finally excrete them. An in-house Mara Labs study confirmed the excretion pathway: microplastics come out in feces. In the original study, the individual measured the highest microplastic levels ever recorded, and a repeat study a year later showed dramatically lower baseline microplastic levels, suggesting consistent use compounds the benefit over time.
You'll Learn:
- Why microplastics accumulate inside lysosomes and what sulforaphane does to release them
- How the three detox pathways, glutathione, glucuronidation, and sulfation, work together to remove every major class of toxin
- What an in-house study revealed about how and where microplastics actually leave the body
- How toxic estrogen metabolites form and why sulforaphane is the most effective natural tool to reroute them
- Why berberine supports sleep optimization, ketosis, and blocks a cancer growth pathway most drugs cannot touch
- How sulforaphane boosts BDNF and neuroplasticity at the cellular level
- What microplastic sources in your home, including your dryer, rugs, and receipts, are doing to your toxin load daily
- Why losing weight releases stored toxins and what to take to protect your brain and metabolism during fat loss
- How sulforaphane activates the same AMPK longevity pathways triggered by fasting without restricting food
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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Dr. John Gildea, David Roberts, Mara Labs, BrocElite, sulforaphane, microplastics, microplastic removal, lysosome, lysosomal surface translocation, detox pathways, glutathione, glucuronidation, sulfation, Nrf2 pathway, AMPK, TFEB1, BDNF, neuroplasticity, heavy metals, BPA, benzene, estrogen metabolism, toxic estrogen, xenoestrogens, berberine, BerbaLite, ResveraLite, c-Myc, cancer and estrogen, sleep optimization, ketosis, broccoli sprouts, isothiocyanates, PEITC, watercress, phase two detox, microplastic excretion, indoor air quality, HEPA filter, dryer lint microplastics, BPA receipts, endocrine disruptors, fat loss and toxins, autism and sulforaphane, ADHD and focus, vivid dreams and BDNF, fasting mimicry, anti-aging, biohacking, longevity, functional medicine, supplements, human performance, brain optimization, metabolism, cellular detox
Resources:
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Timestamps:
0:00 – Trailer
1:55 – Intro & Context
4:48 – Microplastics & Sulforaphane
12:39 – Broccoli Sprouts Formulation
15:20 – Lab Origin Story
26:01 – Reducing Toxin Exposure
37:06 – Estrogen, Hormones & Berberine
52:46 – Autism, ADHD & Brain Health
59:01 – Wrap-Up
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Transcript
Click on a timestamp to play from that location
| 0:00.0 | I want to get all of my calories from Mother Nature and all of my nutrients from Mother Nature. |
| 0:04.9 | That is fantastic, as long as you would only get your toxins from Mother Nature. |
| 0:08.6 | And unfortunately, last I checked, she wasn't making microplastics. |
| 0:11.7 | There's a big problem with microplastics. |
| 0:14.2 | They're finding a substantial amount of human brain tissue. |
| 0:17.0 | They've found them in ovaries and testes, even in semen these days. Sulforaphane, in newly |
| 0:24.1 | discovered research, helps you dump microplastics. Sulforaphane, we try to talk about, just focus |
| 0:30.3 | on, you know, a handful of its benefits, but it has 39 pro-health benefits of the science |
| 0:35.4 | literature. Do you know something that excretes BPA from the body? |
| 0:39.3 | Yeah, for sure. |
| 0:40.0 | Sophoraphane. |
| 0:42.2 | You're listening to the Human Upgrade with Dave Asprey. |
| 0:50.3 | Poor recovery speeds up aging. |
| 0:52.4 | When you don't recover from stress properly, your cells get weaker and accumulate damage. Heart math changes that. The inner balance coherence plus trains your body to recover at the source, your nervous system. The setup is pretty simple. You connect a sensor to your ear that pairs to the heartMath app, which guides you through an HRV exercise. |
| 1:14.0 | In five minutes a day, your body shifts out of stress mode and into coherence, the state where recovery, focus, and peak performance happen. |
| 1:22.8 | Most devices only track recovery. HeartMath trains it. |
| 1:26.4 | It works by targeting heart rate variability or |
| 1:29.1 | HRV, your body's most reliable marker of resilience. Higher HRV means faster recovery, |
| 1:36.2 | deeper sleep, and stronger performance. Decades of science prove that heart math works. Over 400 |
| 1:42.3 | studies show measurable results in as little as six weeks. |
| 1:46.3 | That means less anxiety, better sleep, more energy, and sharper focus. That's why elite athletes, |
| 1:52.0 | hospitals, and the U.S. military all use the Interbalance Coherence Plus. This is one of the things |
... |
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