So on a great day, your brain is firing in a rhythm.

In every wonderful memory you've ever had,

your brain is firing in a rhythm that feels good.

That's being in sync.

And so the ability to re-synchronize your brain

so that you can get back into your life

and you can feel in sync with the world,

that generally lands with people.

And it has the benefit of being true.

Music that generally lands with people. And it has the benefit of being true. Welcome to the Carlythe Psychiatry podcast, keeping psychiatry honest since 2003.

I'm Chris Aiken, the editor-in-chief of the Carlat Psychiatry Report.

And I'm Kelly Newsom, a psychiatric MP and a dedicated reader of

every issue. In the summer of 2024, I set out to write a book about treatment-resistant

depression. I thought I had the material covered. Over the past 25 years, I've tried novel medications

and behavioral therapies for patients who did not respond to anything else.

Cramapaxol, cellicoxib, minocycline, omega-3, ketamine-assisted psychotherapy, but the book

took me down a different path. as new trials came out suggesting that medications

may not be the most effective way to get people out of these thick and difficult depressions.

Trials like ascertained TRD, which showed us what many have suspected from meta-analyses all along,

TMS, transcranial magnetic stimulation is more effective than adding aeropipyprazol to an antidepressant.

They randomized 278 patients with treatment-resistant depression into three groups.

The first got TMS, the second got Eopipyproprozole augmentation,

...