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TED Health

How our changing DNA keeps us alive | Linda Chelico

TED Health

TED

Shoshana Ungerleider, Ted Shoshana, Ted Talks Health, Health & Fitness, How To Be Healthier, Medicine, Fitness

4.01.5K Ratings

🗓️ 17 March 2026

⏱️ 20 minutes

🧾️ Download transcript

Summary

DNA carries the code for carrying out biological life, yet DNA is an unstable molecule. The reality is that DNA in all organisms is in a dynamic state with its environment, constantly becoming damaged and undergoing processes for damage reversal and repair. In this TEDx talk, Dr. Linda Chelico, a professor who research spans biochemistry, virology, and cancer biology, discuss how understanding DNA can lead to new insights on cancer treatments.



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Transcript

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0:00.0

This is TED Health, a podcast from TED, and I'm your host, Dr. Shoshana Ungerleiter.

0:07.3

When it comes to the biggest medical questions we're still trying to answer, like why we age,

0:13.7

why cancer develops, and how some bodies seem to resist it better than others.

0:18.7

Humans are actually just one data point. Think about it. Evolution has

0:23.4

been running experiments for billions of years, across millions of species. So it just makes sense that

0:29.7

some of the most illuminating lessons about health and longevity can come from paying attention

0:34.4

to the natural world around us, noticing who's thriving, and then asking

0:38.9

how. We can learn so much from other species, and that idea is what led me to this week's

0:45.3

what caught my attention segment. My initial curiosity came from an unlikely place.

0:52.7

The genome of a whale, and not just any whale, but the bowhead whale. An animal that

0:59.7

can live more than 200 years grows to be larger than the size of a city bus, and somehow

1:05.9

manages to do all of that without being overwhelmed by cancer. From a biological perspective, that combination of size and lifespan should be a disaster.

1:17.6

More years alive usually means more time for DNA damage to accumulate.

1:23.6

More cells means more opportunities for mutations to go wrong.

1:28.5

And yet, bowhead whales seem to defy that math.

1:32.0

A new paper in nature digs into how they pull this off,

1:35.3

and the new research stopped me in my tracks.

1:39.5

So for a long time, scientists thought that animals that grow very large and live very long must protect

1:45.9

themselves by being especially ruthless at the cellular level. So their bodies might quickly

1:51.8

eliminate damaged cells before they can cause trouble. That's actually part of how elephants

1:56.6

stay healthy, for example. But biology rarely works in clean either-or categories. And it turns out,

2:04.5

most species use a mix of strategies, balancing when to remove damage cells and when to actually

...

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