How Long Does It Take to Become Vitamin B12-Deficient and What Are the Symptoms?
NutritionFacts.org Video Podcast
Michael Greger, M.D. FACLM
4.8 • 951 Ratings
🗓️ 12 November 2025
⏱️ 5 minutes
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| 0:00.0 | In these next five videos, I'm going to be covering everything vitamin B12. |
| 0:04.5 | How fast B12 deficiency can set in the earliest signs to watch out for, |
| 0:09.5 | why standard blood tests can miss it, and just how dangerous it can be left untreated. |
| 0:15.5 | Most importantly, the best way to protect yourself. For those eating plant-based diets, encouragement of vitamin B12 supplementation cannot be over-emphasized. |
| 0:33.6 | What happens if you don't get enough B12? |
| 0:36.6 | Well, the vitamin is necessary for the synthesis of DNA, |
| 0:41.2 | so a deficiency in B12 can cause pretty much anything. |
| 0:45.0 | Brain problems, psychiatric problems, sensory problems, constitutional problems, muscle problems, nerve problems. |
| 0:51.1 | It can also cause clotting disorders and bleeding disorders. It can make people |
| 0:55.8 | catatonic, hallucinate, psychotic, even suicidal. One patient got electroshock therapy before |
| 1:03.9 | they realized, oops, he was just B-12 deficient. Even more tragic are life-threatening manifestations of B-12 deficiency in infants when their moms aren't supplementing. |
| 1:16.6 | Coma, respiratory failure, severe brain damage. |
| 1:20.6 | VindB12 deficiency in pregnancy is the diagnosis not to miss. |
| 1:26.6 | I've done B-12 videos like this over and over again over the years. |
| 1:32.2 | Can we just stick to the consensus clinical guidelines and preventing, diagnosing, and treating |
| 1:37.5 | B12 deficiency? No, we can't because there aren't any. There are lots of recommendations out there, but little robust evidence to back them up. |
| 1:48.1 | They're based more on assumptions than solid clinical evidence. |
| 1:52.1 | That's why you'll see papers like this, how I treat vitamin B-12 deficiency. |
| 1:57.7 | Why should we care what some random doctor does? Because there aren't a lot of clear-cut answers everyone agrees upon. |
| 2:04.6 | For example, it is currently unknown how long it takes for vitamin B-12 deficiency to occur |
| 2:10.6 | in someone going completely plant-based without supplementing with B-12 or B-12-fortified foods. |
| 2:16.6 | This textbook suggested it might take as long as 10 or 20 years, but that was based on a study |
... |
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