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Daniel and Kelly’s Extraordinary Universe

How do parasites evade our immune system? (featuring Dr. John Hawdon)

Daniel and Kelly’s Extraordinary Universe

iHeartPodcasts

Astronomy, Physics, Science, Natural Sciences

4.62.5K Ratings

🗓️ 11 November 2025

⏱️ 48 minutes

🧾️ Download transcript

Summary

Daniel and Kelly chat with Dr. John Hawdon about how parasites like hookworm, malaria, and schistosomes hide from our immune system.

See omnystudio.com/listener for privacy information.

Transcript

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0:00.0

This is an I-Heart podcast.

0:04.3

Howdy, friends?

0:05.4

Just a heads up that we're talking about parasites again.

0:08.2

And as you're probably aware of by now, that can get pretty gross.

0:12.4

Also, it's kind of upsetting to hear about parasite life cycles and the effects of parasites on our health.

0:17.0

I get that.

0:17.8

Today, we're going to be talking about malaria, schistocymiasis, and hookworm.

0:21.5

So decide if those are topics you are prepared to hear about. All right, here we go.

0:29.6

According to the World Health Organization, in 2023, about 263 million people were infected by malaria,

0:41.2

of which 597,000 passed away from this disease. Most of these deaths happened in Africa,

0:47.7

and 76% of the deaths were children under five. You might remember from a past episode that we were able to create a vaccine for smallpox

0:56.4

and that that vaccine was used to wipe smallpox off the face of the planet, saving

1:01.8

humanity from this ancient scourge.

1:04.0

And yes, thanks to all who wrote in, I pronounce the word correctly now.

1:08.1

We also have vaccines for other bacterial and viral infections like polio, chickenpox,

1:13.0

human papillomavirus, COVID-19, measles, mumps, etc. With the exception of some tricky viruses

1:19.8

like HIV which hide in our immune cells, we've had a lot of success making vaccines for viral

1:25.6

and bacterial infections.

1:32.2

And we know that our immune systems attack big stuff, as well as the little stuff like bacteria and viruses.

1:34.0

In a past episode, we talked about how our immune systems will attack entire organs following

1:39.3

a transplant.

1:40.5

So why do our immune systems seem to do such a crummy job of attacking parasites in our bodies, things like nematodes?

...

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