Hormone Replacement Therapy Decoded: Why the FDA Removed the Blackbox Warning on HRT
The Dr. Gabrielle Lyon Show
Dr. Gabrielle Lyon
4.5 • 1.2K Ratings
🗓️ 23 December 2025
⏱️ 63 minutes
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Timestamps:
0:00 - FDA Lifts Blackbox Warning on HRT
1:08 - Definitions: Viralization & Androgens
3:08 - The New Landscape of Women's Health
4:46 - Gold Standard Testing: Mass-Spec
5:52 - Finding the Estrogen Sweet Spot for Men
8:07 - Testosterone Lab Ranges for Women
10:16 - Is Testosterone Safe for Women?
13:30 - Anabolic vs. Androgenic Steroids
16:56 - HRT Red Flags: Who Should Not Start
18:19 - Longevity Benefits of HRT
21:23 - Estrogen's Role in Brain Health
24:32 - Performance Impact in Young Women
33:03 - Type 2 Muscle Hypertrophy
37:06 - Monitoring Hematocrit & Safety
41:44 - Delivery: Injections vs. Gels
42:31 - How TRT Can Mask Anemia
46:36 - Impact on Cholesterol & Lipids
51:48 - Non-Negotiable Baseline Lab Panels
53:23 - Case Study: 60-Year-Old Transformation
58:15 - The Future of FDA Approval
59:06 - Can DHEA Move the Needle?
Transcript
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| 0:00.0 | The FDA just removed the black box warning on HRT for metapops. |
| 0:07.0 | Who should not go on hormone replacement therapy? |
| 0:12.0 | Active breast cancer or active cancer if someone has not worked up vaginal bleeding and stroke. |
| 0:18.0 | Benefits of hormone replacement therapy include a reduced risk of all cause mortality, |
| 0:23.6 | fractures, HRT has also been associated with a 50% reduction in heart attack risk, |
| 0:28.6 | 64% reduction in cognitive decline, 34% lower risk of Alzheimer's. |
| 0:34.6 | We think about testosterone and we think about muscle mass, but there are testosterone receptors all over the body. There are estrogen receptors all over the body. It's not just, oh my gosh, I'm going to give you testosterone and then you're going to grow a beard and muscles. It's not going to happen. You know, we think about testosterone replacement therapy for men. No way blinks and I. Women aren't even thinking about that. Similarly, just how men aren't even thinking about estrogen, which is |
| 0:57.9 | equally important for men and women. Wow. |
| 1:05.3 | What's our friends? I'm Dr. Gabrielle Lyon. And before we jump into this episode, I want to put together a handful of definitions so that we are all on the same page. |
| 1:15.6 | And the first definition that you are going to hear is called virulization. |
| 1:20.6 | And this is the development of male characteristics by being exposed to an androgen, an androgen like testosterone. They include the |
| 1:29.1 | following, deepening in the voice, coarse hair on your body, increase in clitoris, increase in muscle |
| 1:38.9 | mass, and that is called virulization. The second definition that you might hear is something called |
| 1:44.3 | hematicrit. And this is a simple blood test and it refers to the oxygen carrying capacity in the |
| 1:50.2 | blood. The higher your hematicrit, the more oxygen that you carry. The third definition that I think |
| 1:55.8 | is important is something called an androgen. And an androgen is a steroid hormone and this is |
| 2:02.8 | typically related to the development and maintenance of male sex characteristics |
| 2:08.5 | but it's present in both men and women and finally something called liquid chromatography |
| 2:14.7 | and this is a way or a chemical technique that allows us to |
| 2:19.1 | identify certain compounds in the body like testosterone you've heard me say |
| 2:23.8 | before muscle is the organ of longevity now I'm putting the playbook in your |
| 2:29.7 | hands my new book the forever strong playbook is your roadmap to building real |
... |
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