Hormonal Birth Control & Altered Mood States Science Review

High Intensity Health with Mike Mutzel, MS

Mike Mutzel

Fasting, Nutrition, Autophagy, Ketogenic, Keto, Health & Fitness, Ketodiet, Medicine

4.8 • 1.2K Ratings

🗓️ 5 May 2023

⏱️ 16 minutes

🔗️ Recording | iTunes | RSS

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Summary

Hormonal birth control is linked with altered mood states, including anxiety and depression as well as exaggerated responses to stress. Sponsored Message:

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Time Stamps:

00:00 Altered mood states are linked with hormonal birth control.

00:50 IUD’s, other than copper, contain progestins and some have estrogens.

02:00 Elevated depression and stress scores, elevated CRP, and plasma cortisol, are found from hormonal birth control.

04:00 Exaggerated basal neuroendocrine and inflammatory profiles are found with hormonal contraceptive users.

04:20 Hormone users had double the amount of cortisol compared to non-users.

04:40 Synthetic progestins and estrogens are not the same as biologically identical progesterone and estradiol.

07:20 Depression increases your risk from dying from all causes, particularly from cardiovascular disease.

07:45 Neurotransmitter GABA is sensitive to changes in progesterone.

10:50 Neuroactive steroid hormones and the HPAG axis are altered with synthetic hormonal contraceptives.

13:10 History of psychiatric illness increases likelihood of poor mental health while using hormonal contraception.

14:30 Explore birth control alternatives.

Studies Mentioned:

1.Skovlund, C. W., Mørch, L. S., Kessing, L. V. & Lidegaard, Ø. Association of Hormonal Contraception With Depression. Jama Psychiat73, 1154 (2016).

2.Lewis, C. A. et al. Effects of Hormonal Contraceptives on Mood: A Focus on Emotion Recognition and Reactivity, Reward Processing, and Stress Response. Curr Psychiat Rep 21, 115 (2019).

3.Elsayed, M. et al. The potential association between psychiatric symptoms and the use of levonorgestrel intrauterine devices (LNG-IUDs): A systematic review. World J Biological Psychiatry 1–19 (2022) doi:10.1080/15622975.2022.2145354.

4.Raeder, F. et al. Do oral contraceptives modulate the effects of stress induction on one-session exposure efficacy and generalization in women? Psychopharmacology 240, 1075–1089 (2023).

5.Lacasse, J. M., Ismail, N. & Tronson, N. C. Editorial overview: Hormonal contraceptives and the brain: A call for translational research. Front Neuroendocrin 69, 101063 (2023).

6.Martell, S., Marini, C., Kondas, C. A. & Deutch, A. B. Psychological side effects of hormonal contraception: a disconnect between patients and providers. Contracept Reproductive Medicine 8, 9 (2023).

7.Zettermark, S. et al. Population heterogeneity in associations between hormonal contraception and antidepressant use in Sweden: a prospective cohort study applying intersectional multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA). Bmj Open 11, e049553 (2021).

Transcript

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0:00.0	So hormonal birth control has been linked with altered mood states, depression, anxiety,
0:03.9	and poor responses to stress.
0:05.3	And in this video, I want to share with you the science about that because unfortunately,
0:08.5	many women are put on birth control and they suffer from anxiety, depression, and they
0:12.4	think it's just that their body might be broken or that they're genetically prone to having
0:16.0	depressed or anxious states and affect in that way.
0:19.6	But I want to share with you what the research actually shows.
0:22.2	And so if someone in your life is experiencing depression, anxiety, or having suicidal ideation,
0:27.4	and they're also, concomitly, taking hormonal birth control, there's other solutions and
0:31.5	options that you should be aware about.
0:33.3	And I want to link a book by my friend, Jolene Brighton.
0:35.8	The title is, is this normal?
0:37.1	She talks about all sorts of different contraceptives and alternatives to hormonal birth control.
0:42.2	But just recognize that studies actually show, especially young children, young women are
0:46.5	increasingly more likely to experience anxiety, depression, and poor mental health scores.
0:51.2	We know that women in general are more likely to experience anxiety and depression.
0:54.8	And so when we altered their hormones by use of hormonal birth control agents, which
0:58.6	can come in the form of the pill, also hormonal bearing IUDs, these are actually quite common
1:04.1	among women.
1:05.3	We know that the copper IUD does not have synthetic projections, but most of the hormonal
1:08.9	bearing IUDs do have projections and some also have estrogen and the use of these compounds
1:15.8	has been shown to change the way that the human body responds to stress in women.
	...

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