HIV Clarified: Viral Pathogenesis Steps with Researcher Guido Van Marle
Finding Genius Podcast
Richard Jacobs
4.4 • 1K Ratings
🗓️ 5 December 2020
⏱️ 43 minutes
🧾️ Download transcript
Summary
HIV's effect on the gut immune cells appears significant. This implies that gut-associated lymphoid tissue (GALT) stands as a possible viral replication reservoir. Virologist Guido Van Marle is researching how and why this happens and how gut infection affects systemic infection.
Listen in as he and Richard explore every step of HIV infection. They discuss
- What the difference between the acute and dormant stage is and why it's termed dormant rather than latent,
- Why some infected individuals are long-term non progressors and others develop AIDS, and
- What happens when the virus attacks the gut-associated lymphoid tissue and why this is significant.
Guido Van Marle is an associate professor in the Department of Microbiology, Immunology, and Infectious Diseases at the University of Calgary. He focuses on viruses, specifically molecular virology techniques of West Nile Virus and the HIV-1 life cycle. He offers listeners numerous molecular mechanism examples of HIV.
He takes special care to designate the different stages of viral infection, explaining how in the early stage, called the acute or primary infection phase, the virus replicates and destroys some of the immune system cells. When it moves into the dormant stage, this activity dies down and the immune system is able to rebound. Significantly, the gut immune cells don't rebound the way other systems do.
In fact, his research has found that there is high load of infection going on in these gastrointestinal tract cells in that early acute phase post-HIV transmission, which means the area experiences a lot of cell death and inflammation: this allows pathogens to enter the tract and exit into the blood stream.
He explains the molecular mechanisms of biology that lead to leaky gut in this process. Furthermore, when doctors deliver antiviral therapy, and the patient's immune cells increase in number, they don't increase as much in the gut. He has focused on this area of infection for his research with the hopes of understanding disease progression as a whole.
Available on Apple Podcasts: apple.co/2Os0myK
Transcript
Click on a timestamp to play from that location
| 0:00.0 | Forget frequently asked questions common sense common knowledge or Google how about advice from a real genius |
| 0:06.8 | 95% of people in any profession are good enough to be qualified and licensed 5% go and beyond. They become very good at what they do. |
| 0:15.1 | But only 0.1% are real Jesus. |
| 0:18.3 | Richard Jacobs has made it his life's mission to find them for you. |
| 0:22.4 | He hunts down and interviews geniuses in every field, sleep science, cancer, stem cells, |
| 0:27.2 | ketogenic diets, and more. |
| 0:28.8 | Here come the geniuses. |
| 0:30.4 | This is the Finding Genius Podcast. |
| 0:33.0 | That is Richard Jacobs. |
| 0:35.0 | Hello, this is Richard Jacobs with the Finding Genius Podcast. |
| 0:41.0 | I have Gido von Marley. He is an associate professor at University of Calgary in the |
| 0:46.6 | Department of Microbiology, Immunology, and Infectious Diseases. |
| 0:50.0 | So we're going to talk about some of his research surrounding HIV. |
| 0:53.9 | So Gido, thanks for coming. |
| 0:55.8 | Thank you, thanks for inviting me. |
| 0:57.8 | Yeah, tell me about your HIV research. |
| 1:00.1 | What are you looking at? |
| 1:01.8 | Okay, so in HIV, so I'm trained as a virologist and over the years of my |
| 1:07.7 | training and fellowships I became very interested in viral evolution and looking at how HIV |
| 1:16.2 | involves in HIV infected individuals. |
| 1:19.9 | So that is sort of the mainstream of my research at the moment is where we look at how does the virus involve in a particular infected individual? |
| 1:30.6 | How do they differ between individuals and sort of figuring out where the virus hangs out in basically in a infected individual and |
... |
Please login to see the full transcript.
Disclaimer: The podcast and artwork embedded on this page are from Richard Jacobs, and are the property of its owner and not affiliated with or endorsed by Tapesearch.
Generated transcripts are the property of Richard Jacobs and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.
Copyright © Tapesearch 2026.