High Triglycerides more Problematic than High LDL Cholesterol, Science You Should Know
High Intensity Health with Mike Mutzel, MS
Mike Mutzel
4.7 • 1.3K Ratings
🗓️ 30 July 2022
⏱️ 25 minutes
🧾️ Download transcript
Summary
The consensus in the medical community about the importance of low-density lipoprotein cholesterol (LDL-C) reduction is finally shifting. Ample research shows that elevated triglycerides and triglyceride-related lipoproteins are more problematic than LDL-C when it comes to the risk of heart and metabolic disease.
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Link to Video and Research:
Time Stamps: bit.ly/3JjJTbH
0:45 Triglyceride-rich lipoprotein is a hallmark of diabetic dyslipidemia. It cannot be controlled by statins.
4:50 Remnant cholesterol is independently associated with the onset of diabetes.
5:33 Remnant lipoproteins are a consequence of lipid absorption from the GI tract.
6:50 Apo-B is on the extra cellular surface of atherogenic vLDL, IDL, LDL, and remnant lipoprotein.
7:40 HDL have the Apo-A1 protein on the extra-cellular surface.
8:35 Test your Apo-B to Apo-A1 ratio and your vLDL, LDL and remnant lipoprotein assessment.
9:15 IDL and vLDL are enriched in triglycerides and cholesterol and drive inflammatory processes.
9:45 Statins are anti-inflammatory.
10:45 Remnant lipoproteins drive metabolic disease by increasing ectopic lipid deposition.
11:35 Remnant lipoproteins induce endothelial dysfunction.
12:00 Clotting cascades can be driven by remnant lipoproteins.
13:35 Remnant lipoproteins can penetrate the arterial wall and become trapped and oxidized, creating plaque.
15:00 Remnant triglyceride rich lipoproteins are more atherogenic than LDL cholesterol.
15:50 Dietary fat composition can render lipoproteins more oxidizable.
17:00 Request the labs listed on page 1 of the Bloodwork Cheat Sheet. Do fasted labs then non-fasted lipid levels.
18:15 Lipid Load Test: if your blood triglycerides are more than 220 nanograms/ml, you have difficulty processing fats in the post meal window.
18:55 Lose weight, especially around the abdomen.
19:35 Eat a low carb diet.
20:05 Exercise regularly, both resistance training and aerobic exercise.
20:25 Statins lower triglycerides 20 to 30%. They also induce insulin resistance, which increases triglycerides.
20:55 Omega 3 fats reduce triglycerides. Test your omega 3s.
23:05 Optimal fasting triglycerides are around 60 and 70. Postprandial triglycerides should be less than 180.
Transcript
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| 0:00.0 | Hey, Fern, welcome back. |
| 0:01.0 | So in today's show, we're going to focus on the forgotten lipids. |
| 0:03.7 | These are the remnant low-density lipoproteins and the triglycerides. |
| 0:07.2 | I know there's a big focus from the conventional medical system about how to lower your so-called |
| 0:12.0 | bad or LDL cholesterol. |
| 0:13.8 | Well, it turns out after years and years of dropping LDL cholesterol with statins and other |
| 0:19.0 | associated medications, people are still dying from heart disease in very large numbers. |
| 0:24.0 | In fact, as this one study talks about, the title of this paper here is, the rule of remnant |
| 0:28.6 | cholesterol beyond low-density lipoprotein cholesterol in diabetes, malitis. |
| 0:32.2 | I want to share with you just a quote, because it is really telling these are scientists |
| 0:36.4 | who are studying this for living, who are investigating cardiometabolic disease and their |
| 0:41.0 | associations with diabetes and so forth. |
| 0:43.4 | They say, however, with the widespread use of statins in recent years, we have shifted |
| 0:47.8 | our attention to triglyceride-rich lipoproteins, one of the hallmarks of diabetic dyslipidemia |
| 0:53.2 | that cannot be controlled by statins. |
| 0:55.9 | So again, they're not essentially saying that statins are useless, but they are saying, |
| 0:59.5 | hmm, we've been lowering cholesterol by way of statins for years and years, we've focused |
| 1:03.9 | on this. |
| 1:04.9 | Yet heart disease remains to be the number one cause of mortality and develop countries |
| 1:08.4 | throughout the entire world. |
| 1:09.9 | So what exactly are these forgotten lipids? |
| 1:13.2 | We're going to focus today on the remnant lipoproteins and triglycerides. |
... |
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