Our podcast today brings us back to the year 1837 in which we're going to be discussing a disease that transcends inheritance as well as intrigue.

It has to do with concentrates as well as chromosomes.

And with inheritance and chromosomes comes lineage.

And lineage is where the story begins in this podcast that's going to span a few topics.

We're going to be talking about hemophilia and the royal disease. I'm Dr.

Naket-Sahn-Pahl, your friendly-neabored internist and gastrantroologist, and we're going to be continuing the series on

it's all in the blood with a multi-part series on hemophilia.

So let's kick off that music and blood is a pretty synonymous topic with Halloween.

Now, hemophilia and bleeding problems and blood disorders have been discussed since ancient times,

but hemophilia itself was called a royal disease.

And let's talk about why.

It's probably because hemophilia or the gene that was inherited from hemophiliax was

probably passed from Queen Victoria.

It's believed that she was a spontaneous mutation for the gene

and probably had a Hemophilia B carrier state.

She became Queen of England in 1837 to the ruling families of Russia, Spain, and Germany.

Now her mutation was spontaneous, but because it's ex-linked and we'll go into more of the genetics shortly, her children, Leopold, had hemophilia B,

simply because he inherited the X chromosome from her.

She also had two daughters, Alice and Beatrice.

They were carriers. Beatrice's daughter married into the Spanish Royal Family, and that is how

the hemophilia gene moved from England into Western Europe.

Her other daughter, Alice, was also a carrier and a daughter named Alex.

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