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The a16z Show

Healthcare 2026: AI Doctors, GLP-1s, and Insurance Defection

The a16z Show

a16z

Entrepreneurship, Culture, Disruption, Innovation, Science, Software Eating The World, Business, Technology

4.21.2K Ratings

🗓️ 27 January 2026

⏱️ 94 minutes

🧾️ Download transcript

Summary

Out-of-Pocket is a healthcare education company founded by Nikhil Krishnan that helps people understand how healthcare works and how to navigate it in practice. In this episode, a16z investing partner Jay Rughani and Nikhil discuss why health insurance is losing its role as the default way people access care. They explain how rising costs are pushing more consumers to pay out of pocket for diagnostics, preventive care, and navigation. The conversation also looks at what this shift means for startups, AI-powered tools, regulation, and access as healthcare continues to move beyond insurance.

Transcript

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0:00.0

If you go into like our health insurance subreddit, extremely common question now of just, hey, should I just not get health insurance at all?

0:08.3

These are my premiums. This is kind of what I'm paying. This is kind of the drug I need or blah, blah, blah.

0:13.2

And for a lot of people, that answer is actually probably no.

0:15.9

The healthcare system that we have today in the U.S. is drastically supply constraint.

0:22.7

23 million Americans work in health care, yet we've got long wait times, 100 million people plus don't have access to a primary

0:29.3

care doc, 40-day plus wait times to see a doc if you can. The existing health care system, they really

0:36.4

want to create standardized care for people, right,

0:38.3

and standardized guidelines to make medicine good

0:41.3

at the median level for everybody, right?

0:44.0

But at the same time,

0:46.3

people want more agency in their health care in some capacity.

0:50.8

No one wants to be told like, hey, just wait and see.

1:06.0

What happens when Americans start rebuilding healthcare outside the traditional system?

1:13.1

Not because they reject health care, but because the way care is accessed, priced, and delivered no longer matches how people actually use it.

1:17.0

For years, the U.S. healthcare system has been organized around insurance.

1:23.7

The Affordable Care Act expanded coverage and brought the uninsured rate down, and for a time, the system appeared to be stabilizing.

1:30.1

But rising premiums, high deductibles, and limited access have left many consumers paying more while using care less.

1:32.4

In response, behavior is changing.

1:35.1

Some people are opting out of insurance entirely.

1:43.9

Others keep coverage but increasingly pay out of pocket for diagnostics, preventative care, memberships, and digital tools that offer speed, clarity, and control.

1:49.4

Care is moving towards proactive screening, monitoring, and navigation, often outside traditional clinical settings. This shift is not just about consumer frustration. It's reshaping the

1:54.5

healthcare stack itself. New companies are emerging to help people find care, price services,

...

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