Hello and welcome to the Zero to Finals podcast.

My name is Tom and in this episode I'm going to be talking to you about

hemolytic uremic syndrome.

And you can find written notes on this topic at zero to finals.com slash hus or in the

renal medicine section of the second edition of the zero definals medicine book.

And you can find flashcards and questions to train your knowledge on this content

and help you remember the information longer at members.0.0.0.com.

So let's get straight into it.

Hemolytic uremic syndrome, or H-U-S, involves thrombosis or blood clots in the small blood vessels

throughout the body, usually triggered by the shigar toxin, which can come from E. coli

0157 or shigella.

Hemalytic uremic syndrome most often affects children

following an episode of gastroenteritis.

Antibiotics and antimotility medications, for example, laparamide,

used to treat gastroenteritis caused by E. coli 0157 or Shigella, increase the risk of

hemolitic uremic syndrome.

Hemalytic uremic syndrome leads to the classic triad of features of micro-angiopathic

hemalytic anemia, acute kidney injury, and thrombocytopinia, or low platelets.

Micro-angiopathic hemolytic amoeia, or maha, involves the destruction of red blood cells, or hemolysis,

due to pathology in small blood vessels.

Tiny blood clots or thrombi partially obstruct the small blood vessels

and churn up the red blood cells as they pass through, causing the red blood cells to rupture,

...