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Science Quickly

Gut Microbes Lessen Mice Malarial Malaise

Science Quickly

Scientific American

Science

4.2639 Ratings

🗓️ 12 February 2016

⏱️ 3 minutes

🧾️ Download transcript

Summary

Mice with the right mix of microbes were spared the worst of a malaria infection, possibly via some sort of "booster effect" on the immune system. Christopher Intagliata reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

Understanding the human body is a team effort. That's where the Yachtel group comes in.

0:05.8

Researchers at Yachtolt have been delving into the secrets of probiotics for 90 years.

0:11.0

Yacold also partners with nature portfolio to advance gut microbiome science through the global grants for gut health, an investigator-led research program.

0:19.6

To learn more about Yachtolt, visit yawcult.co.

0:22.7

.j.p. That's Y-A-K-U-L-T.C-O.J-P. When it comes to a guide for your gut, count on Yacult.

0:33.7

This is Scientific American's 60-second science. I'm Christopher Entagata. Got a minute?

0:39.9

A malaria infection begins when a mosquito injects the plasmodium parasite into the blood.

0:45.3

But getting sick is not a certain outcome.

0:47.9

The vast majority of people really only develop either mild malaria or even asymptomatic infections.

0:55.0

Nathan Schmidt, a cellular immunologist at the University of Louisville.

0:59.0

It's a very small subset of the hundreds of millions of cases that progressed to severe malaria.

1:06.0

Now, some of the variation in illness severity is genetic, or whether the patient's partially immune,

1:11.7

thanks to past exposures. But Schmidt and his colleagues have found another factor that could

1:16.6

influence the disease, the host microbiome. The first clue came during an experiment in lab mice,

1:23.3

because even though the mice were almost identical genetically, mice that had been bought from

1:27.6

different vendors showed variability in their response to infection by the malaria parasite.

1:33.0

Turns out, the mice had different microbiomes.

1:36.4

So the researchers did more tests.

1:38.3

They transplanted the gut bugs of both the resistant and the susceptible animals into other

1:42.7

mice that had no gut bacteria. And again,

1:46.0

mice that now had the resistant microbial mix were spared the worst of a malaria infection,

1:52.0

possibly through some sort of booster effect on their immune system, thanks to the microbes.

...

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