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This Week in Startups

Grok 4 Beats OpenAI + The $300 AI Agent Era | E2150

This Week in Startups

Jason Calacanis

Technology

4.41.3K Ratings

🗓️ 12 July 2025

⏱️ 71 minutes

🧾️ Download transcript

Summary

Today’s show: Grok 4 just leapfrogged OpenAI to become the top AI model—and it’s not just hype. In this episode, @Jason and @alex break down Grok’s AGI-level performance, the massive drop in LLM pricing, and why some companies are raising prices anyway. They also dive into the Missouri AG’s investigation into AI “bias,” the future of First Amendment protections for LLMs, and how autonomous vehicles are creating a new category: “autonomous commerce.” If you’re building with AI or betting on the future of tech, don’t miss this one.


Timestamps:

(1:55) AI models: Grok 4 and performance benchmarks(3:51) Detailed analysis of AI model performance and price trends(10:11) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(11:25) AI models' problem-solving capabilities and timeline for solving math problems(16:53) Legal and regulatory challenges for AI

(19:56) Retool - Visit https://www.retool.com/twist and try it out today.(21:12) Bias in AI models and political implications(30:41) Vouched - Trust for agents that’s built for builders like you. Check it out at http://vouched.id/twist(32:07) Infinite energy potential and AI impact; Bitcoin's new high(37:11) Crypto regulation and fintech under new administration(45:50) Future of storage, computing power, and GPU lifespan in data centers(53:40) Claude segment by Anthropic(55:09) Guest Ben Seidl of Autolane introduction(57:19) Autolane's impact on autonomous vehicles and commerce(59:05) Rise of autonomous commerce and logistics(1:06:37) Retailer issues with autonomous vehicle integration and orchestration


Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

Check out the TWIST500: https://www.twist500.com

Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


Follow Lon:

X: https://x.com/lons


Follow Alex:

X: https://x.com/alex

LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm


Follow Jason:

X: https://twitter.com/Jason

LinkedIn: https://www.linkedin.com/in/jasoncalacanis


Thank you to our partners:

(10:11) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist

(19:56) Retool - Visit https://www.retool.com/twist and try it out today.(30:41) Vouched - Trust for agents that’s built for builders like you. Check it out at http://vouched.id/twist


Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland


Check out Jason’s suite of newsletters: https://substack.com/@calacanis


Follow TWiST:

Twitter: https://twitter.com/TWiStartups

YouTube: https://www.youtube.com/thisweekin

Instagram: https://www.instagram.com/thisweekinstartups

TikTok: https://www.tiktok.com/@thisweekinstartups

Substack: https://twistartups.substack.com


Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

Transcript

Click on a timestamp to play from that location

0:00.0

The internet is filled.

0:01.4

You'd be finally shocking, Alex, and I'm sure the audience will as well, with biased people.

0:07.2

There are people on the internet who are not straight shooters.

0:10.7

They're not calling balls and strikes.

0:12.0

They're on a team.

0:13.7

Oh, really?

0:14.7

Yes.

0:15.0

And when they state facts about a person, they may use colorful language or, you know, compare them to Hitler, Idi Amin, Stalin,

0:24.8

etc. And they're doing it in bad faith.

0:30.4

This week in startups is brought to you by Lemon.io.

0:34.9

Hire pre-vetted remote developers and get 15% off your first four weeks of developer time at Lemon. I.O. Hire pre-vetted remote developers and get 15% off your first four weeks of developer time

0:40.3

at lemon.com slash twist. Retool. Bridge the gap between AI demos and business impact with technology

0:48.5

that's designed for developers and built for the enterprise. Visit retool.com slash twist and try it out today.

0:56.3

And Vouched.

0:57.8

Turn your AI infrastructure into production grade software with Know Your Agent from Vouchd.

1:03.3

Check it out yourself at Vouchd. ID slash Twist.

1:07.1

Trust for agents that are built for builders like you.

1:09.6

All right, everybody, welcome back to this week in startups.

1:12.3

I'm your host, Jason Calacanis.

1:13.4

With me again, my co-host, Alex Wilhelm.

1:15.0

We've got a full docket for you on a Friday, July 11th.

1:19.4

Crypto at an all-time high.

...

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