Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Eric Christensen.

Thank you so much for listening today. As always, go check out Real Life Pharmacology.com.

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A great little resource refresher if you're out in clinical practice or if you're preparing

for pharmacology exams or board exams of any type.

So with that, let's get into the drug of the day today.

And technically, it's probably not classified as a drug.

So today's a little bit of a special episode per request.

I've had some dietitians reach out over time, as well as some pharmacy folks,

medication folks too, inquiring about grapefruit juice and what to do with it,

how to handle it, that type of thing.

And while I'll say there certainly isn't one set answer on exactly what to do,

there are a lot of potential drug interactions with grapefruit juice.

And I wanted to, A, kind of outline how that works and why there is drug interactions.

Talk about grapefruit juice a little bit specifically, as well as, you know, kind of talking about the dose dependence of grapefruit juice.

Also, clinical changes, alteration and intake.

And then, of course, you know, some of the most common drugs that you're going to see. And I'm not going to go through an all-inclusive list.

I'm going to, as I typically do with drug interactions, I'm going to go through some of the most common ones that you're actually going to see in clinical practice.

So with that said, let's cover a little bit of the basics here.

So grapefruit juice causes drug interactions by inhibiting SIP 3A4.

Now, SIP 3A4 is basically an enzyme that breaks down drugs. And in all honesty,

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