GLP-1s, “Fibermaxxing,” and Pooping: A Gastroenterologist Explains the Gut-Brain Connection
Gloss Angeles
Kirbie Johnson and Sara Tan
4.6 • 772 Ratings
🗓️ 10 March 2026
⏱️ 37 minutes
🧾️ Download transcript
Summary
This week we’re joined by gastroenterologist and gut-brain researcher Dr. Trisha Pasricha, author of the upcoming book You’ve Been Pooping All Wrong. We talk about everything you’ve always wanted to know about your gut but were too embarrassed to ask: from fiber intake and her preferred supplements to “horrendous period poops,” GLP-1’s and your gut, and why stress can wreak havoc on digestion. Dr. Pasricha explains how the brain-gut connection shapes everything from bloating to anxiety and shares the daily habits that can help you reach what she calls “poophoria.” Plus, we answer listener questions about probiotics, digestive enzymes, gluten confusion, and the red flags women should never ignore when it comes to colorectal health.
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Transcript
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| 0:00.0 | G-M, Los Angeles. |
| 0:05.6 | Hi, Kirby. |
| 0:07.1 | Hi, Sarah. |
| 0:08.4 | Welcome to Los Angeles. |
| 0:14.4 | So my favorite people to follow on social media are experts. |
| 0:18.5 | Of those experts, my favorites, are doctors. |
| 0:22.8 | And our guests, I should say, |
| 0:28.9 | is one of my favorite doctors to follow on social media. I have learned so much. Dr. Tricia Paschika is a physician scientist at Beth Israel Deaconess Medical Center, an assistant professor of medicine |
| 0:33.9 | at Harvard Medical School, and the director of the Institute for Gut Brain Research. |
| 0:38.2 | She's also the Ask a Dr. Calmus for the Washington Post. |
| 0:42.1 | She is a double fellowship trained gastroenterologist from Massachusetts General Hospital |
| 0:47.0 | and currently leads an NIH-funded laboratory investigating the complex communication between |
| 0:52.7 | the brain and the gut. |
| 0:53.7 | And her highly anticipated new book, |
| 0:56.1 | You've Been Pooping All Wrong, comes out April 7th. Welcome to Los Angeles. |
| 1:01.8 | Dr. Trisha. How are you? Great. I am so delighted to be here. Thanks for having me. |
| 1:06.5 | Of course. It's fun seeing you IRL compared to just when we're scrolling on our phones. |
| 1:11.0 | Likewise. Like what you guys are just as amazing in person. Thank you. We usually ask our |
| 1:15.2 | guest what's on our face, but I would love to know what's in your tummy. What did you eat today? |
| 1:20.4 | I had a salad and coffee. So if you hear if the microphone's picking up any rumblings, that's my |
| 1:26.0 | intestinal gas. Okay. Oh, love that. |
| 1:29.7 | What's like your usual meal for a day? Like, are you trying to balance out the fiber, the protein? |
... |
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